Dendritic cell metabolism.

Dendritic cell metabolism.
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DOI:
10.1038/nri3771
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发表时间:
2015-01
期刊:
Nature reviews. Immunology
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--
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其他
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过去 15 年里,我们对受体和信号系统的理解取得了巨大进展,这些系统使树突状细胞 (DC) 能够对病原体或其他危险信号做出反应,并启动先天性和适应性免疫反应。我们现在开始认识到,许多这些途径不仅刺激控制 DC 免疫功能的基因表达的变化,而且还影响代谢途径,从而整合激活过程的细胞要求。在这篇综述中,我们重点关注这个相对较新的研究领域,并试图描述 DC 免疫代谢的综合观点。
The past 15 years have seen enormous advances in our understanding of the receptor and signalling systems that allow dendritic cells (DCs) to respond to pathogens or other danger signals and initiate innate and adaptive immune responses. We are now beginning to appreciate that many of these pathways not only stimulate changes in the expression of genes that control DC immune functions, but also affect metabolic pathways, thereby integrating the cellular requirements of the activation process. In this Review, we focus on this relatively new area of research and attempt to describe an integrated view of DC immunometabolism.
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