Methods to quantify the relation between disease progression in paired eyes
Methods to quantify the relation between disease progression in paired eyes
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DOI：
10.1093/oxfordjournals.aje.a010140
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发表时间：
2000-05-15
影响因子：
5
通讯作者：
Rosner, B
中科院分区：
文献类型：
--
作者：
Glynn, RJ;Rosner, B
在糖尿病视网膜病变的情况下，作者比较了量化一只眼疾病进展程度的替代方法增加另一只眼随后进展的风险。收集了参与1983-1988年索比尼尔视网膜病变试验的478名美国胰岛素依赖型糖尿病患者的数据，并进行了中位数41个月的随访。在此期间，93只右眼和77只左眼发生了糖尿病视网膜病变。左眼进展后，右眼进展的粗发生率是左眼的7.7倍，右眼进展后，左眼是左眼的4.4倍。在调整了随时间增加的进展速度和基线风险因素后的眼特定比例风险模型中，右眼与另一只眼进展相关的可比相对风险为2.6(95%可信区间：1.5，4.7)，左眼为1.4(95%可信区间：0.72，2.9)。两个替代比例风险模型包括双眼的数据并考虑了它们的相关性，估计的相对风险分别为1.9(95%CI：1.2，2.9)和2.7(95%CI：1.8，3.5)。更复杂的联合生存模型整合了双眼的信息，提供了比单独分析右眼或左眼更稳定的估计。
The authors compared, in the context of diabetic retinopathy, alternative methods of quantifying the extent to which disease progression in one eye increases the risk of subsequent progression in the other eye. Data were gathered on 478 US patients with insulin-dependent diabetes mellitus who participated in the 1983-1988 Sorbinil Retinopathy Trial and were followed up for a median of 41 months. During that time, diabetic retinopathy progressed in 93 right eyes and 77 left eyes. Crude incidence rates of progression for right eyes were 7.7 times higher after the left eye had progressed and, for left eyes, were 4.4 times higher after the right eye had progressed. In eye-specific proportional hazards models that adjusted for increasing rates of progression over time and for baseline risk factors, the comparable relative risks associated with progression in the other eye were 2.6 (95% confidence interval (CI): 1.5, 4.7) for right eyes and 1.4 (95% CI: 0.72, 2.9) for left eyes. Two alternative proportional hazards models that included data on both eyes and accounted for their correlation produced estimated relative risks of 1.9 (95% Cl: 1.2, 2.9) and 2.7 (95% CI: 1.8, 3.5), respectively. The more complex models for joint survival integrate information on both eyes and provide more stable estimates than do separate analyses of right or left eyes.