Flat adenomas in a colon cancer-prone kindred.
Flat adenomas in a colon cancer-prone kindred.
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扁平腺瘤存在于易患结肠癌的家族中。
DOI：
10.1093/jnci/80.4.278
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Appelman,HD
中科院分区：
文献类型：
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作者：
Lynch,HT;Smyrk,T;Lanspa,SJ;Marcus,JN;Kriegler,M;Lynch,JF;Appelman,HD
我们描述了一个遗传性非息肉病性结直肠癌家族的新病理学发现。受影响的家族成员发展为多发性小腺瘤，以右侧为主;许多腺瘤具有不寻常的外观，其特征在于轻微升高的病变，腺瘤性变化仅限于结肠隐窝的上部区域。我们采用先前建立的术语“扁平腺瘤”来描述这些病变。这种表型可能是遗传性非息肉病性结直肠癌至少一个亚群的形态学标志。[J Natl Cancer Inst 1988;80：278-282]
We describe new pathologic findings in a hereditary nonpolyposis colorectal cancer family. Affected family members developed multiple small adenomas with right-sided predominance; many adenomas had an unusual appearance featuring slightly elevated lesions with adenomatous changes confined to the upper regions of the colonic crypts. We have adopted the previously established term “flat adenoma” for these lesions. This phenotype may be a morphologic marker for at least one subset of hereditary nonpolyposis colorectal cancer. [J Natl Cancer Inst 1988;80:278–282]