Interim FDG PET/CT for Predicting the Outcome in Patients with Head and Neck Cancer
Interim FDG PET/CT for Predicting the Outcome in Patients with Head and Neck Cancer
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DOI：
10.1002/lary.24826
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发表时间：
2014-12-01
期刊：
影响因子：
2.6
通讯作者：
Kao, Chia-Hung
中科院分区：
文献类型：
--
作者：
Chen, Shang-Wen;Hsieh, Te-Chun;Kao, Chia-Hung
目的/假设本研究旨在探讨头颈癌患者根治性放疗（RT）或放化疗（CRT）期间中期（18）氟-2-脱氧-D-葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）的预后效果。研究设计这是一项前瞻性治疗研究。方法51例患者的治疗前和中期PET/CT图像 对接受明确 RT/CRT 的晚期咽癌患者进行了前瞻性评估。中期 PET/CT 图像是在累积 RT 剂量范围为 41.4 至 46.8 Gy 时拍摄的。测量临时 PET/CT 的最大标准化摄取值 (SUVm) 和两幅图像之间 SUVm 的减少率 (SRR)。使用曼-惠特尼检验检查有或没有局部失败的患者之间的差异。使用 Kaplan-Meier 方法计算总生存期 (OS)、无病生存期 (DFS) 以及原发性和淋巴结无复发生存率。使用 Cox 回归分析确定独立的预测因素。结果中位随访时间为 23 个月后，较高的中期 SUVm 与局部失败相关。进行多变量分析显示，原发肿瘤的 SUVmax 减少率 (SRR-P)
Objectives/HypothesisThe study aimed to investigate the prognostic effects of interim (18)fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (PET/CT) during definitive radiotherapy (RT) or chemoradiotherapy (CRT) in patients with head and neck cancer.Study DesignThis is a prospectively treatment study.MethodsThe pretreatment and interim PET/CT images of 51 patients with advanced pharyngeal cancers receiving definitive RT/CRT were evaluated prospectively. The interim PET/CT images were taken at a cumulative RT dose ranging from 41.4 to 46.8 Gy. The maximum standardized uptake value (SUVm) of the interim PET/CT and the reduction ratio of the SUVm (SRR) between the two images were measured. The differences between patients with or without local failures were examined using the Mann-Whitney test. Overall survival (OS), disease-free survival (DFS), and primary and nodal relapse-free survival rates were calculated using the Kaplan-Meier method. Independent prognosticators were identified using Cox regression analysis.ResultsAfter a median follow-up duration of 23 months, a higher interim SUVm was associated with local failures. Conducting a multivariate analysis revealed that a SUVmax reduction ratio of primary tumor (SRR-P)