Task-specific neural activity in the primate prefrontal cortex
Task-specific neural activity in the primate prefrontal cortex
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DOI：
10.1152/jn.2000.84.1.451
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Miller, EK
中科院分区：
文献类型：
--
作者：
Asaad, WF;Rainer, G;Miller, EK
现实世界的行为通常比刺激和反应之间的一对一映射更为复杂；同样的刺激可以根据不同的情况导致不同的行为，或者同样的行为可以由不同的刺激引起。在这种情况下，需要了解手头任务的正式要求。我们发现，在训练猴子在三种任务之间交替时，前额皮质中许多神经元的活动是任务依赖的。这包括总体放电速率、放电速率曲线（随时间变化的反应形状）以及刺激和反应选择性的变化。这些发现支持了一个假设，即前额叶的主要功能是获取和执行任务背景和用于指导行为的“规则”。
Real-world behavior is typically more complicated than a one-to-one mapping between a stimulus and response; the same stimulus can lead to different behaviors depending on the situation, or the same behavior may be cued by different stimuli. In such cases, knowledge of the formal demands of the task at hand is required. We found that in monkeys trained to alternate between three tasks, the activity of many neurons in the prefrontal cortex was task dependent. This included changes in overall firing rate, in firing-rate profiles (shape of responses over time), and in stimulus and response selectivity. These findings support the hypothesis that a major prefrontal function is the acquisition and implementation of task context and the "rules" used to guide behavior.