Effectiveness of recruitment in clinical trials: An analysis of methods used in a trial for irritable bowel syndrome patients
Effectiveness of recruitment in clinical trials: An analysis of methods used in a trial for irritable bowel syndrome patients
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DOI：
10.1016/j.cct.2007.08.004
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发表时间：
2008-03-01
影响因子：
2.2
通讯作者：
Davis, Roger B.
中科院分区：
文献类型：
--
作者：
Feman, Siu Ping Chin;Nguyen, Long I.;Davis, Roger B.
一个成功的临床试验取决于招募。2003年12月至2006年2月，我们的团队成功招募了289名参与者，进行了一项大型、单中心、随机安慰剂对照试验（RCT），研究医患关系和针灸对肠易激综合征（IBS）患者的影响。本文报道了医生推荐、报纸广告、传单、音频和视频媒体（广播和电视广告）等标准招聘方法的有效性，以及互联网广告、公共交通车辆广告和电影院预告等相对较新的招聘方法。我们还报告了每种方法消耗的成本比例和每种方法产生的招聘比例。每个潜在参与者的通话成本从3美元到103美元不等，每个注册参与者的成本从12美元到584美元不等。使用一种新的度量，功效指数，我们发现医生推荐和传单是我们试验中最有效的招募方法。尽管有些方法比其他方法更有效，但所有方法都有助于成功招聘。在招聘活动中反复使用功效指数可能有助于校准和关注最有效的招聘方法。(C) 2007爱思唯尔公司版权所有。
A successful clinical trial is dependent on recruitment. Between December 2003 and February 2006, our team successfully enrolled 289 participants in a large, single-center, randomized placebo-controlled trial (RCT) studying the impact of the patient-doctor relationship and acupuncture on irritable bowel syndrome (IBS) patients. This paper reports on the effectiveness of standard recruitment methods such as physician referral, newspaper advertisements, fliers, audio and video media (radio and television commercials) as well as relatively new methods not previously extensively reported on such as internet ads, ads in mass-transit vehicles and movie theater previews. We also report the fraction of cost each method consumed and fraction of recruitment each method generated. Our cost per call from potential participants varied from $3-$103 and cost per enrollment participant varied from $12-$584. Using a novel metric, the efficacy index, we found that physician referrals and flyers were the most effective recruitment method in our trial. Despite some methods being more efficient than others, all methods contributed to the successful recruitment. The iterative use of the efficacy index during a recruitment campaign may be helpful to calibrate and focus on the most effective recruitment methods. (C) 2007 Elsevier Inc. All rights reserved.