Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications
Quantitative Susceptibility Mapping: Basic Methods and Clinical Applications
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DOI：
10.1148/rg.210054
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发表时间：
2022-07-01
期刊：
影响因子：
5.5
通讯作者：
Miyata, Mari
中科院分区：
文献类型：
--
作者：
Harada, Taisuke;Kudo, Kohsuke;Miyata, Mari
定量磁化率作图（Quantitative susceptibility mapping， QSM）是一种先进的磁共振成像磁化率评价技术，可以对磁化率的空间分布进行精确的定量测量。磁化率描述了材料对外加磁场的磁化能力，是一种物质特有的值。近年来，QSM已被广泛用于脑内各种物质水平的估计，包括铁、含铁血黄素、脱氧血红蛋白（顺磁性）以及钙化（抗磁性）。通过可视化铁在大脑中的分布，可以识别在常规图像上不明显的解剖结构，并评估各种神经退行性疾病。由于呼吸和心跳产生的运动伪影，以及脂肪的存在（与质子的频率不同），将QSM应用于大脑以外的区域一直具有挑战性。本文简要介绍了MRI相位图像转换为QSM的理论背景和方法。此外，我们还对QSM的临床应用现状进行了综述。(c) rsna, 2022
Quantitative susceptibility mapping (QSM), one of the advanced MRI techniques for evaluating magnetic susceptibility, offers precise quantitative measurements of spatial distributions of magnetic susceptibility. Magnetic susceptibility describes the magnetizability of a material to an applied magnetic field and is a substance-specific value. Recently, QSM has been widely used to estimate various levels of substances in the brain, including iron, hemosiderin, and deoxyhemoglobin (paramagnetism), as well as calcification (diamagnetism). By visualizing iron distribution in the brain, it is possible to identify anatomic structures that are not evident on conventional images and to evaluate various neurodegenerative diseases. It has been challenging to apply QSM in areas outside the brain because of motion artifacts from respiration and heartbeats, as well as the presence of fat, which has a different frequency to the proton. In this review, the authors provide a brief overview of the theoretical background and analyze methods of converting MRI phase images to QSM. Moreover, we provide an overview of the current clinical applications of QSM. (C) RSNA, 2022