Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxide
Evidence of cardiovascular protection by moderate alcohol: Role of nitric oxide
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DOI：
10.1016/j.freeradbiomed.2005.04.007
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发表时间：
2005-08-15
影响因子：
7.4
通讯作者：
Parks, DA
中科院分区：
文献类型：
--
作者：
Abou-Agag, LH;Khoo, NK;Parks, DA
流行病学证据表明，适量饮酒可降低心脏病的发病率。内皮一氧化氮合酶 (eNOS) 通过控制一氧化氮（(NO)-N-中心点）的产生，是血管稳态和心肌功能的关键调节剂。这些研究的目的是确定与酒精相关的明显心脏保护作用是否部分是通过调节心血管系统中的 eNOS 蛋白和活性来介导的。给大鼠喂食酒精，并在 8 周结束时评估 eNOS 蛋白和 (NO)-N 中心点的产生。对一部分动物的心肌和血管功能进行离体评估。适量酒精可改善缺血后心肌收缩和舒张功能，并减轻缺血后冠状血管阻力的降低。适量酒精还可使最大血管舒张增加 26 +/- 0.2%，并增加血浆 (NO)-N 中心点的产生，同时 eNOS 蛋白增加超过 2.5 倍。较高浓度的酒精会使最大血管松弛度降低 22 +/- 0.1%。这些结果表明，适量酒精可改善缺血后心肌功能并增加血管内皮细胞产生的 (NO)-N 中心点。 (NO)-N-中心点的增加至少可以部分解释适度饮酒的心脏保护作用。 (c) 2005 Elsevier Inc. 保留所有权利。
Epidemiological evidence indicates that moderate alcohol consumption reduces the incidence of heart disease. Endothelial nitric oxide synthase (eNOS) is a key regulator of vascular homeostasis and myocardial functions through the controlled production of nitric oxide ((NO)-N-center dot). These studies were conducted to determine if the apparent alcohol-associated cardioprotection is mediated, in part, through modulation of the eNOS protein and activity in the cardiovascular system. Rats were fed alcohol and eNOS protein and (NO)-N-center dot production were evaluated at the end of 8 weeks. Myocardial and vascular function was assessed ex vivo in a subset of animals. Moderate alcohol improved postischemic myocardial systolic and diastolic function and attenuated the postischemic reduction in coronary vascular resistance. Moderate alcohol also enhanced maximum vascular relaxation by 26 +/- 0.2% and increased plasma (NO)-N-center dot production concomitant with a greater than 2.5-fold increase in eNOS protein. Higher levels of alcohol impaired maximum vascular relaxation by 22 +/- 0.1%. These results suggest that moderate alcohol improves postischemic myocardial functions and increases (NO)-N-center dot production by vascular endothelium. An increase in (NO)-N-center dot may explain, at least in part, the cardioprotective benefits of moderate alcohol consumption. (c) 2005 Elsevier Inc. All rights reserved.