Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative.
Dietary glycemic load, glycemic index, and carbohydrate and risk of breast cancer in the Women's Health Initiative.
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妇女健康倡议中的膳食血糖负荷、血糖指数、碳水化合物和乳腺癌风险。
DOI：
10.1080/01635581.2011.587227
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tinker,Lesley
中科院分区：
文献类型：
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作者：
Shikany,JamesM;Redden,DavidT;Neuhouser,MarianL;Chlebowski,RowanT;Rohan,ThomasE;Simon,MichaelS;Liu,Simin;Lane,DorothyS;Tinker,Lesley
饮食血糖负荷（GL）、血糖指数（GI）和碳水化合物可能通过影响长期血糖和胰岛素浓度而与乳腺癌风险相关。我们在148，767名女性健康倡议（WHI）参与者中研究了GL，GI和碳水化合物与乳腺癌发病率之间的关系。根据基线时的食物频率问卷估计饮食变量。随访期间自我报告的乳腺癌通过病历审查得到证实。考克斯比例风险回归在GL、GI和碳水化合物的五分位数内建模至乳腺癌的时间。在中位随访8.0年后，共有6，115例乳腺癌。我们观察到GL、GI或碳水化合物与乳腺癌总发病率之间无关联，风险比和95%置信区间最高与最低五分位数分别为1.08、0.92-1.29（趋势P = 0.27）; 1.01，0.91-1.12（P= 0.74）; 0.95，0.80-1.14（P= 0.98）。GL与原位癌之间的正相关有显著性趋势（1.40，0.94-2.13;P= 0.07）。虽然没有证据表明GL，GI或碳水化合物与WHI参与者的总乳腺癌风险之间存在关联，但GL与原位癌风险之间存在关联的建议需要进一步调查。
Dietary glycemic load (GL), glycemic index (GI), and carbohydrate could be associated with breast cancer risk by influencing long-term blood glucose and insulin concentrations. We examined associations between GL, GI, and carbohydrate and incident breast cancer in 148,767 Women's Heath Initiative (WHI) participants. Dietary variables were estimated from food frequency questionnaires administered at baseline. Self-reported breast cancers during follow-up were confirmed by medical records review. Cox proportional hazards regression modeled time to breast cancer within quintiles of GL, GI, and carbohydrate. There were 6,115 total breast cancers after a median follow-up of 8.0 yr. We observed no associations between GL, GI, or carbohydrate and total incident breast cancer, with hazard ratios and 95% confidence intervals for the highest vs. lowest quintiles of 1.08, 0.92–1.29 (Pfor trend = 0.27); 1.01, 0.91–1.12 (P= 0.74); and 0.95, 0.80–1.14 (P= 0.98), respectively. There was a trend toward significance for the positive association between GL and in situ cancers (1.40, 0.94–2.13;P= 0.07). Although there was no evidence of associations between GL, GI, or carbohydrate and total breast cancer risk in WHI participants, the suggestion of an association between GL and risk of in situ cancers requires further investigation.