Cerebral microbleeds: a guide to detection and interpretation.
Cerebral microbleeds: a guide to detection and interpretation.
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DOI：
10.1016/s1474-4422(09)70013-4
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发表时间：
2009-02
期刊：
影响因子：
48
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
--
作者：
Greenberg, Steven M.;Vernooij, Meike W.;Cordonnier, Charlotte;Viswanathan, Anand;Salman, Rustorn Al-Shahi;Warach, Steven;Launer, Lenore J.;Van Buchem, Mark A.;Breteler, Monique M. B.
脑微出血（CMB）是越来越被认可的神经影像学发现，发生在脑血管疾病、痴呆和正常衰老中。近年来已经取得了实质性的进展，特别是在开发用于CMB检测的新MRI方法并将其应用于基于人群的老年样本方面。这篇综述的重点是这些最近的发展及其对两个主要问题的影响：如何检测CMB，以及如何解释它们。现在有充分的证据表明，CMB的流行率和检测数量随MRI特征（如脉冲序列、序列参数、空间分辨率、磁场强度和后处理）而变化，强调了MRI技术在解释研究中的重要性。最近使用敏感技术的调查发现，在社区居住的老年人中检测到的CMB患病率惊人地高。我们提出了识别CMB的程序指南，并建议未来可能的方法来阐明这些常见病变作为小血管脑疾病的标志物和潜在贡献者的作用。
Cerebral microbleeds (CMB) are increasingly recognized neuroimaging findings, occurring with cerebrovascular disease, dementia, and normal aging. Recent years have seen substantial progress, particularly in developing newer MRI methodologies for CMB detection and applying them to population-based elderly samples. This review focuses on these recent developments and their impact on two major questions: how CMB are detected, and how they should be interpreted. There is now ample evidence that prevalence and number of detected CMB varies with MRI characteristics such as pulse sequence, sequence parameters, spatial resolution, magnetic field strength, and post-processing, underlining the importance of MRI technique in interpreting studies. Recent investigations using sensitive techniques find the prevalence of CMB detected in community-dwelling elderly to be surprisingly high. We propose procedural guidelines for identifying CMB and suggest possible future approaches for elucidating the role of these common lesions as markers for, and potential contributors to, small vessel brain disease.