Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys
Role of CD8+ lymphocytes in control and clearance of measles virus infection of rhesus monkeys
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DOI：
10.1128/jvi.77.7.4396-4400.2003
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发表时间：
2003-04-01
影响因子：
5.4
通讯作者：
Letvin, NL
中科院分区：
文献类型：
--
作者：
Permar, SR;Klumpp, SA;Letvin, NL
为全球麻疹控制开发改进的疫苗需要了解控制麻疹病毒的免疫机制。为了评估CD8(+)细胞毒性T淋巴细胞在麻疹病毒清除中的作用，通过输注单克隆抗CD8抗体来消除恒河猴的CD8(+)淋巴细胞，并用野生型麻疹病毒进行攻击。与对照抗体治疗的动物相比，CD8+淋巴细胞耗尽的动物表现出更广泛的皮疹、病毒复制高峰时更高的病毒载量以及更长的病毒血症持续时间。这些发现表明CD8+淋巴细胞在控制麻疹病毒感染中的核心作用以及在新的麻疹疫苗策略中引发细胞介导的免疫反应的重要性。
The creation of an improved vaccine for global measles control will require an understanding of the immune mechanisms of measles virus containment. To assess the role of CD8(+) cytotoxic T lymphocytes in measles virus clearance, rhesus monkeys were depleted of CD8(+) lymphocytes by monoclonal anti-CD8 antibody infusion and challenged with wild-type measles virus. The CD8(+) lymphocyte-depleted animals exhibited a more extensive rash, higher viral loads at the peak of virus replication, and a longer duration of viremia than did the control antibody-treated animals. These findings indicate a central role for CD8(+) lymphocytes in the control of measles virus infections and the importance of eliciting a cell-mediated immune response in new measles vaccine strategies.