Microbiota from young mice counteracts selective age-associated behavioral deficits
Microbiota from young mice counteracts selective age-associated behavioral deficits
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DOI：
10.1038/s43587-021-00093-9
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发表时间：
2021-08-01
期刊：
影响因子：
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通讯作者：
Cryan, John F.
中科院分区：
文献类型：
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作者：
Boehme, Marcus;Guzzetta, Katherine E.;Cryan, John F.
肠道微生物群越来越被认为是宿主免疫力和大脑健康的重要调节器。衰老过程会导致微生物群发生巨大变化，这与老年人的健康状况较差和脆弱有关。然而，在衰老过程中，肠道微生物群在大脑健康和神经免疫中的机械作用的证据有限。因此，我们将来自年轻（3-4个月）或年老（19-20个月）供体小鼠的粪便微生物群移植到年老受体小鼠（19-20个月）中。来自年轻供体的微生物群的移植逆转了外周和脑免疫的衰老相关差异，以及衰老受体小鼠的海马代谢组和转录组。最后，年轻供体来源的微生物群在移植到老年宿主中时减弱了认知行为中的选择性年龄相关障碍。我们的研究结果表明，肠道微生物组可能是促进健康衰老的合适治疗靶点。肠道微生物组可以随着年龄的变化而变化，并系统地影响衰老相关疾病，包括大脑中的疾病。作者表明，通过从年轻小鼠移植粪便微生物群来恢复肠道微生物群，可以逆转海马免疫系统、代谢组和转录组中衰老诱导的缺陷，并挽救选择性认知缺陷。
The gut microbiota is increasingly recognized as an important regulator of host immunity and brain health. The aging process yields dramatic alterations in the microbiota, which is linked to poorer health and frailty in elderly populations. However, there is limited evidence for a mechanistic role of the gut microbiota in brain health and neuroimmunity during aging processes. Therefore, we conducted fecal microbiota transplantation from either young (3-4 months) or old (19-20 months) donor mice into aged recipient mice (19-20 months). Transplant of a microbiota from young donors reversed aging-associated differences in peripheral and brain immunity, as well as the hippocampal metabolome and transcriptome of aging recipient mice. Finally, the young donor-derived microbiota attenuated selective age-associated impairments in cognitive behavior when transplanted into an aged host. Our results reveal that the microbiome may be a suitable therapeutic target to promote healthy aging.The gut microbiome can change with age and influence aging-related diseases systemically, including in the brain. The authors show that rejuvenation of the gut microbiome by fecal microbiota transplantation from young mice reverses aging-induced deficits in the hippocampal immune system, metabolome and transcriptome, and rescues selective cognitive deficits.