Peripheral nervous system: A promising source of neuronal progenitors for central nervous system repair.
Peripheral nervous system: A promising source of neuronal progenitors for central nervous system repair.
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外周神经系统：中枢神经系统修复的神经元祖细胞的一个有前途的来源。
DOI：
10.3389/fnins.2022.970350
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发表时间：
2022
影响因子：
4.3
通讯作者：
Goldstein, Allan M.
中科院分区：
文献类型：
--
作者：
Mueller, Jessica L.;Stavely, Rhian;Hotta, Ryo;Goldstein, Allan M.
关键词：
随着人口的不断老龄化，神经系统疾病的患病率不断增加。鉴于缺乏有效的治疗策略以及中枢神经系统（CNS）内源性再生的能力有限，迫切需要更好地了解神经系统修复的外源性策略。干细胞疗法为促进神经组织和功能的修复提供了一种有前途的方法，但迄今为止的研究受到各种因素的限制，包括从中枢神经系统收获供体细胞的挑战、有关使用胚胎或胎儿组织的伦理问题、诱导多能干细胞的致瘤潜力以及非自体细胞来源的免疫介导的排斥反应。在这里，我们回顾并提出了两种用于 CNS 修复的来自周围神经系统 (PNS) 的自体细胞的替代来源：肠神经元干细胞 (ENSC) 和皮下脂肪组织中发现的神经嵴衍生的雪旺细胞 (称为 SAT-NSC)。 ENSCs可以成功地从出生后肠神经系统中分离出来，在体外增殖，并通过直接脑内注射和全身尾静脉注射成功移植到CNS损伤模型中。同样，SAT-NSC 可以很容易地从人和小鼠的脂肪组织中分离出来，尽管尚未在中枢神经系统损伤模型中使用，但已成功移植到结肠神经节缺失和胃轻瘫模型中并恢复其功能。这些独特的三七总皂苷衍生自体细胞来源为中枢神经系统干细胞疗法提供了令人兴奋的选择，因为它们已被证明具有神经源性潜力，并消除了对致瘤风险、伦理考虑和免疫介导排斥反应的担忧。
With a steadily aging population there is an increasing prevalence of neurological disorders. Given the lack of effective treatment strategies and a limited ability for the central nervous system (CNS) to regenerate endogenously, there is a critical need to better understand exogenous strategies for nervous system repair. Stem cell therapy offers a promising approach to promote the repair of neurologic tissue and function, however studies to date have been limited by various factors including challenges in harvesting donor cells from the CNS, ethical concerns regarding use of embryonic or fetal tissue, tumorigenic potential of induced pluripotent stem cells, and immune-mediated rejection of non-autologous cell sources. Here we review and propose two alternative sources of autologous cells derived from the peripheral nervous system (PNS) for CNS repair: enteric neuronal stem cells (ENSCs) and neural crest-derived Schwann cells found in subcutaneous adipose tissue (termed SAT-NSCs). ENSCs can be successfully isolated from the postnatal enteric nervous system, propagated in vitro, and transplanted successfully into models of CNS injury via both direct intracerebral injection and systemic tail vein injection. Similarly, SAT-NSCs can be readily isolated from both human and mouse adipose tissue and, although not yet utilized in models of CNS injury, have successfully been transplanted and restored function in models of colonic aganglionosis and gastroparesis. These unique sources of PNS-derived autologous cells offer an exciting option for stem cell therapies for the CNS as they have proven neurogenic potential and eliminate concerns around tumorigenic risk, ethical considerations, and immune-mediated rejection.
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影响因子：
3.6
作者：
Cheng, Lily S.;Hotta, Ryo;Goldstein, Allan M.
通讯作者：
Goldstein, Allan M.
影响因子：
16.6
作者：
McCann, Conor J.;Cooper, Julie E.;Thapar, Nikhil
通讯作者：
Thapar, Nikhil
影响因子：
3.7
作者：
Kumagai G;Okada Y;Yamane J;Nagoshi N;Kitamura K;Mukaino M;Tsuji O;Fujiyoshi K;Katoh H;Okada S;Shibata S;Matsuzaki Y;Toh S;Toyama Y;Nakamura M;Okano H
通讯作者：
Okano H
DOI：
10.1093/brain/awr094
发表时间：
2011-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Andres RH;Horie N;Slikker W;Keren-Gill H;Zhan K;Sun G;Manley NC;Pereira MP;Sheikh LA;McMillan EL;Schaar BT;Svendsen CN;Bliss TM;Steinberg GK
通讯作者：
Steinberg GK
脂肪衍生的间充质干细胞通过miR-25的细胞外囊泡转移减少了中风小鼠的自噬。
影响因子：
16
作者：
Kuang Y;Zheng X;Zhang L;Ai X;Venkataramani V;Kilic E;Hermann DM;Majid A;Bähr M;Doeppner TR
通讯作者：
Doeppner TR