Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex
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DOI：
10.1038/s41467-019-10490-9
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发表时间：
2019-06-19
影响因子：
16.6
通讯作者：
Boisbouvier, Jerome
中科院分区：
文献类型：
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作者：
Gauto, Diego F.;Estrozi, Leandro F.;Boisbouvier, Jerome
原子分辨率结构测定对于理解蛋白质功能至关重要。冷冻-EM和NMR光谱都提供结构信息，但目前冷冻-EM不能常规地获得原子级结构数据，并且，通常，NMR结构测定仅限于小的（
Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (