Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays
Electrochemical deposition and characterization of poly(3,4-ethylenedioxythiophene) on neural microelectrode arrays
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DOI：
10.1016/s0925-4005(02)00448-3
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发表时间：
2003-03-01
影响因子：
8.4
通讯作者：
Martin, DC
中科院分区：
文献类型：
--
作者：
Cui, XY;Martin, DC
微机械神经微电极与神经组织之间的界面在活体神经记录中起着重要的作用。采用电化学聚合的方法对金属电极表面进行了优化。从水溶液中将聚(3，4-乙二氧基噻吩基)(PEDOT)/聚苯磺酸盐(PSS)电化学沉积在神经探针的微电极上。PEDOT/PSS涂层使阻抗模数降低了近两个数量级。采用等效电路模型分析了沉积薄膜的电学特性。阻抗数据支持开放的、模糊的薄膜形态，这也在扫描电子显微镜图像中得到证明。这种开放的结构缩短了有效扩散长度，并允许离子在薄膜上快速传输。与前人对聚吡咯的研究相比，PEDOT表现出更好的电化学稳定性。以乙腈/水(1：1)为溶剂进行电化学聚合，将生物活性多肽DCDPGYIGSR引入PEDOT膜中。PEDOT/DCDPGYIGSR包被探针与大鼠神经胶质细胞共培养，细胞在包被区优先生长。PEDOT/DCDPGYIGSR涂层电极可以获得高质量的急性神经记录。(C)2002 Elsevier Science B.V.保留所有权利。
The interface between micromachined neural microelectrodes and neural tissue plays an important role in neural recording in vivo. Electrochemical polymerization was used to optimize the surface of the metal electrode sites. Poly(3,4-ethylenedioxythiophene) (PEDOT)/ poly(styrene sulfonate) (PSS) was electrochemically deposited on the microelectrodes of neural probes from aqueous solution. The PEDOT/ PSS coating decreases the impedance modulus by almost two orders of magnitude. An equivalent circuit model was adopted to analyze the electrical characteristics of the deposited film. Impedance data support an open, fuzzy film morphology that is also demonstrated in SEM images. This open structure shortens the effective diffusion length and allows fast ion transport across the film. In comparison with a previous study on polypyrrole, PEDOT demonstrated much better electrochemical stability. The bioactive peptide DCDPGYIGSR was incorporated in the PEDOT film during the electrochemical polymerization from the solvent mixture of acetonitrile/H2O (1:1). PEDOT/DCDPGYIGSR coated probes were cultured with rat glial cells and preferential growth of cells was seen on the coated area of the probes. High quality acute neural recordings can be obtained through PEDOT/DCDPGYIGSR coated electrodes. (C) 2002 Elsevier Science B.V. All rights reserved.