Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI
Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI
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DOI：
10.1111/j.1552-6569.2006.00069.x
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Smith, Eric E.
中科院分区：
文献类型：
--
作者：
Nandigam, R. N. Kaveer;Chen, Yu-Wei;Smith, Eric E.
背景和目的：我们试图确定在使用相对较厚（6-7 mm）矢状切片的回顾性数据时，中矢状颅内面积（ICA）是否是颅内容积（ICV）的有效替代指标。方法：对 47 名受试者的数据进行回顾性分析，这些受试者接受了两次至少相隔 9 个月的 MRI 扫描。 23 名受试者在 T2 加权序列上对 ICV 进行了手动分割以进行比较。结果：观察者内、观察者间和观察者内扫描-再扫描比较的组内相关系数 (ICC) 分别为 0.96、0.97 和 0.95。 ICV 和 ICA 之间的 Pearson 相关系数（对最中线切片的累积 1、2、3 和 4 个进行平均）分别为 0.89、0.94、0.93 和 0.95。通过测量两个而不是一个切片，ICV 的解释方差显着增加 (P = 0.001)。结论：这些数据表明，即使没有高分辨率成像进行测量，ICA 也是 ICV 的合理替代品。
Background and Purpose: We sought to determine whether mid-sagittal intracranial area (ICA) is a valid surrogate of intracranial volume (ICV) when using retrospective data with relatively thick (6-7 mm) sagittal slices. Methods: Data were retrospectively analyzed from 47 subjects who had two MRI scans taken at least nine months apart. Twenty-three subjects had manual segmentation of ICV on the T2-weighted sequence for comparison. Results: Intraclass correlation coefficient (ICC) for intraobserver, interobserver, and intraobserver scan-rescan comparisons were 0.96, 0.97 and 0.95. Pearson correlation coefficients between ICV and ICA, averaging the cumulative 1, 2, 3, and 4 most midline slices, were 0.89, 0.94, 0.93, and 0.95. There was a significant marginal increase in explained variance of ICV by measuring two, rather than one, slices (P = 0.001). Conclusions: These data suggest that ICA, even measured without high-resolution imaging, is a reasonable substitute for ICV.