Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
Obesity Differs from Diabetes Mellitus in Antibody and T Cell Responses Post COVID-19 Recovery
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DOI：
10.1101/2023.06.14.23291375
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发表时间：
2023-06
影响因子：
4.6
通讯作者：
M. Ali;S. Longet;I. Neale;P. Rongkard;F. Chowdhury;J. Hill;A. Brown;S. Laidlaw;T. Tipton
中科院分区：
文献类型：
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作者：
M. Ali;S. Longet;I. Neale;P. Rongkard;F. Chowdhury;J. Hill;A. Brown;S. Laidlaw;T. Tipton
目的：肥胖和2型糖尿病（DM）是严重COVID-19结局的风险因素，对南亚人群的影响不成比例。本研究旨在调查孟加拉国患有肥胖和糖尿病的成年COVID-19幸存者对SARS-CoV-2的体液和细胞免疫应答。研究方法：在这项横断面研究中，在2020年COVID-19大流行的第一波疫苗接种前，研究了孟加拉国63名健康和75名PCR确认的COVID-19康复者的SARS-CoV-2特异性抗体和T细胞反应。结果：在COVID-19幸存者中，SARS-CoV-2感染诱导了强烈的抗体和T细胞应答，这与疾病的严重程度相关。在调整了年龄、性别、DM状态、疾病严重程度和自症状发作以来的时间后，肥胖与中和抗体滴度降低、SARS-CoV-2刺突特异性IFN-γ应答增加沿着CD 8 + T细胞增殖和IL-2产生增加相关。相比之下，在调整肥胖和其他混杂因素后，糖尿病与SARS-CoV-2特异性抗体和T细胞反应无关。结论：肥胖与COVID-19恢复后较低的中和抗体水平和较高的SARS-CoV-2 T细胞应答相关，而糖尿病患者的抗体或T细胞应答保持不变。
Objective: Obesity and type 2 diabetes (DM) are risk factors for severe COVID-19 outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with obesity and DM in Bangladesh. Methods: In this cross-sectional study, SARS-CoV-2-specific antibody and T cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020. Results: In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, obesity was associated with decreased neutralising antibody titers, and increased SARS-CoV-2 spike-specific IFN-{gamma} response along with increased proliferation and IL-2 production by CD8+ T cells. In contrast, DM was not associated with SARS-CoV-2-specific antibody and T cell responses after adjustment for obesity and other confounders. Conclusions: Obesity is associated with lower neutralising antibody levels and higher T cell responses to SARS-CoV-2 post COVID-19 recovery, while antibody or T cell responses remain unaltered in DM.