Evidence of muscle BOLD effect revealed by simultaneous interleaved gradient-echo NMRI and myoglobin NMRS during leg ischemia
Evidence of muscle BOLD effect revealed by simultaneous interleaved gradient-echo NMRI and myoglobin NMRS during leg ischemia
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DOI：
10.1002/mrm.1910400408
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发表时间：
1998-10-01
影响因子：
3.3
通讯作者：
Carlier, PG
中科院分区：
文献类型：
--
作者：
Lebon, V;Brillault-Salvat, C;Carlier, PG
这项工作的目的是研究骨骼肌中 T-2（星）加权 NMR 图像的强度变化与通过肌红蛋白质子 NMR 光谱测量的组织氧含量之间的时间关系。在缺血应激测试期间，在 3 特斯拉下研究了五名健康志愿者的小腿肌肉，使用了交错的 NMRI-NMRS 序列，这使得同时记录 T-2（星）加权图像和肌红蛋白光谱成为可能。缺血期间，在 T-2（星）加权图像上观察到肌肉信号强度的快速变化，这发生在肌红蛋白去饱和之前。考虑到血红蛋白和肌红蛋白各自的 P-50，这一观察结果显然支持血红蛋白去饱和导致 T-2（星号）变化的假设。实验核磁共振数据与仅源自生理考虑的血红蛋白去饱和模型之间的时间一致性进一步支持了这种解释。
The purpose of this work was to investigate the temporal relationship between intensity changes in T-2(star)-weighted NMR images and tissue oxygen content, measured by myoglobin proton NMR spectroscopy, in the skeletal muscle, During an ischemic stress test, the calf muscles of five healthy volunteers were studied at 3 Tesla, An interleaved NMRI-NMRS sequence was used, which made it possible to record T-2(star)-weighted images and myoglobin spectra simultaneously. During ischemia, rapid changes in muscle signal intensity were observed on T-2(star)-weighted images, which immediately preceded myoglobin desaturation. Bearing in mind the respective P-50 of hemoglobin and myoglobin, this observation clearly favored the hypothesis that hemoglobin desaturation was responsible for the changes in T-2(star). This interpretation was further supported by the temporal coincidence between the experimental NMR data and a model of hemoglobin desaturation solely derived from physiological considerations.