Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders.
Genome-wide association study of facial emotion recognition in children and association with polygenic risk for mental health disorders.
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DOI：
10.1002/ajmg.b.32558
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Eley TC
中科院分区：
文献类型：
--
作者：
Coleman JRI;Lester KJ;Keers R;Munafò MR;Breen G;Eley TC
情绪识别在许多精神健康疾病中被破坏，这可能反映了这种特征和这些疾病之间的共同遗传病因。我们探讨了遗传对情绪识别的影响以及这些影响与心理健康表型之间的关系。来自雅芳父母和儿童纵向研究（ALSPAC）的8岁参与者（n = 4，097）完成了非语言准确性诊断分析（DANVA）面部测试。全基因组基因型数据可从Illumina HumanHap550 Quad微阵列获得。进行了全基因组关联研究，以评估与个人情绪和一般情绪识别的关联。使用已发表的精神分裂症、双相情感障碍、抑郁症、自闭症谱系障碍、厌食症和焦虑症的基因组数据进行探索性多基因风险评分。在任何分析中均未在常规显著性水平下鉴定出个体遗传变异，尽管几个基因座在提示显著性的水平下相关。SNP芯片遗传力分析未发现任何表型的遗传方差分量。多基因评分与任何表型无关。影响情绪识别的变量的效应大小可能很小。以前的情绪识别研究已经产生了SNP遗传性的非零估计值。这种差异可能是由于表型的测量和分析的差异。
Emotion recognition is disrupted in many mental health disorders, which may reflect shared genetic aetiology between this trait and these disorders. We explored genetic influences on emotion recognition and the relationship between these influences and mental health phenotypes. Eight‐year‐old participants (n = 4,097) from the Avon Longitudinal Study of Parents and Children (ALSPAC) completed the Diagnostic Analysis of Non‐Verbal Accuracy (DANVA) faces test. Genome‐wide genotype data was available from the Illumina HumanHap550 Quad microarray. Genome‐wide association studies were performed to assess associations with recognition of individual emotions and emotion in general. Exploratory polygenic risk scoring was performed using published genomic data for schizophrenia, bipolar disorder, depression, autism spectrum disorder, anorexia, and anxiety disorders. No individual genetic variants were identified at conventional levels of significance in any analysis although several loci were associated at a level suggestive of significance. SNP‐chip heritability analyses did not identify a heritable component of variance for any phenotype. Polygenic scores were not associated with any phenotype. The effect sizes of variants influencing emotion recognition are likely to be small. Previous studies of emotion identification have yielded non‐zero estimates of SNP‐heritability. This discrepancy is likely due to differences in the measurement and analysis of the phenotype.
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DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
影响因子：
30.8
作者：
Bulik-Sullivan, Brendan K.;Loh, Po-Ru;Finucane, Hilary K.;Ripke, Stephan;Yang, Jian;Patterson, Nick;Daly, Mark J.;Price, Alkes L.;Neale, Benjamin M.
通讯作者：
Neale, Benjamin M.
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
6.8
作者：
Germine L;Robinson EB;Smoller JW;Calkins ME;Moore TM;Hakonarson H;Daly MJ;Lee PH;Holmes AJ;Buckner RL;Gur RC;Gur RE
通讯作者：
Gur RE
影响因子：
7.6
作者：
Goodman, R;Ford, T;Meltzer, H
通讯作者：
Meltzer, H