Update in acute pancreatitis.
Update in acute pancreatitis.
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DOI：
10.1007/s11894-010-0091-6
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发表时间：
2010-04-01
影响因子：
--
通讯作者：
Conwell, Darwin L
中科院分区：
文献类型：
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作者：
Wu, Bechien U;Conwell, Darwin L
急性胰腺炎是住院治疗的常见原因，在美国和世界范围内带来了巨大的疾病负担。最近的报告涵盖了广泛的主题，包括腺泡细胞pH微环境的新见解，腺泡细胞命运的信号通路，和先天免疫反应。临床研究人员报道了评估疾病严重程度的新方法，管理局部并发症的创新技术，早期识别胰腺或胰腺外感染的重要性，以及预防疾病复发。最近的数据还表明，专门的中心可能有利于重症急性胰腺炎的管理。这篇综述总结了一些基础和临床科学的最新进展，重点是与管理急性胰腺炎患者的临床医生相关的发现。
Acute pancreatitis is a common cause for hospitalization that carries a substantial burden of disease in the United States and worldwide. Recent reports have encompassed a wide array of topics including new insights into the acinar cell pH microenvironment, signal pathways for acinar cell fate, and the innate immune response. Clinical researchers have reported new methods to assess disease severity, innovative techniques for management of local complications, the importance of early recognition of pancreatic or extrapancreatic infection, and prevention of disease recurrence. Recent data also suggest that specialized centers may be of benefit for the management of severe acute pancreatitis. This review summarizes a number of recent advances in basic and clinical science with an emphasis on findings that are relevant to clinicians who manage patients with acute pancreatitis.