Evaluation of subjective assessment of liver function from radionuclide images.
Evaluation of subjective assessment of liver function from radionuclide images.
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根据放射性核素图像对肝功能进行主观评估。
DOI：
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发表时间：
1987
影响因子：
2.6
通讯作者：
B. Diffey
中科院分区：
文献类型：
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作者：
J. Jago;C. J. Gibson;B. Diffey
99 Tcm-胶体显像出现非肝摄取是肝功能不良的重要指标。我们进行这项研究，以评估有经验的观察员的能力，以评估肝功能放射性核素图像。本文用一个简单的模型模拟了99 Tcm-胶体在肝脏、脾脏和骨髓中的分布随肝功能和肝脏质量的变化。从真实的研究中分离出这三个器官的合适图像，并将其用作“模板”来创建逼真的模拟99 Tcm-胶体图像，其中肝、脾和骨髓的计数密度由模型确定。这些图像以随机顺序呈现给几位观察者，要求他们评估肝功能。与真实功能的估计比较表明，视觉评估是系统不准确的，低估了不良功能和高估了良好的功能。它也是不精确的，特别是对于只有中度功能受损的肝脏。观察者也受到肝脏质量变化的影响，更容易判断小肝脏异常。我们建议使用定量技术进行客观评估，应作为肝功能评价目视检查的辅助手段。
The appearance of non-hepatic uptake in 99Tcm-colloid images is an important indicator of poor liver function. We undertook this study to evaluate the ability of experienced observers to assess liver function from radionuclide images. A simple model was used to simulate the changing distribution of 99Tcm-colloid in the liver, spleen and bone marrow as the liver function and mass were varied. Suitable images of these three organs were isolated from real studies and used as "templates" to create realistic simulated 99Tcm-colloid images, with the count densities of liver, spleen and bone marrow determined by the model. These images were presented in random order to several observers, who were asked to assess liver function. Comparison of the estimated with the true function shows that visual assessment is systematically inaccurate, with underestimation of poor function and overestimation of good function. It is also imprecise, especially for livers with only midly impaired function. Observers were also affected by changing liver mass and were more likely to judge small livers to be abnormal. We suggest that objective assessment using a quantitative technique should be used as an adjunct to visual inspection for the evaluation of liver function.