Effects of tricyclic antidepressants on platelet monoamine oxidase activity.
Effects of tricyclic antidepressants on platelet monoamine oxidase activity.
复制标题
三环类抗抑郁药对血小板单胺氧化酶活性的影响。
DOI：
10.1038/clpt.1984.72
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发表时间：
1984
影响因子：
6.7
通讯作者：
Lisansky,J
中科院分区：
文献类型：
--
作者：
Reyes,E;Lisansky,J
本研究中的8名受试者被诊断为患有原发性或继发性抑郁症，并接受阿米替林治疗，100至300 mg/天。测定阿米替林治疗前后血小板单胺氧化酶（MAO）的活性。单胺氧化酶活性的预处理值为17.94 ~ 44.89 U。阿米替林治疗后，数值范围为0.66 - 41.94 U，平均下降50.2%。这些结果与三环类抗抑郁药至少部分通过抑制MAO而起作用的假设相一致，Clinical Pharmacology and Therapeutics（1984）35，531 -534; doi：10.1038/clpt.1984.72
The eight subjects in this study were diagnosed as having primary or secondary depression and were treated with amitriptyline, 100 to 300 mg/day. Activity of platelet monoamine oxidase (MAO), an enzyme responsible for the degradation of biogenic amines, was determined before and after treatment with amitriptyline. Pretreatment values for MAO activity ranged from 17.94 to 44.89 U. After amitriptyline the values ranged from 0.66 to 41.94 U, a mean decrease of 50.2%. These results are consistent with the hypothesis that the tricyclic antidepressants act, at least in part, by inhibition of MAO.Clinical Pharmacology and Therapeutics(1984)35,531–534; doi:10.1038/clpt.1984.72