Prevalence of chronic obstructive pulmonary disease in rural women of Tamilnadu: implications for refining disease burden assessments attributable to household biomass combustion
Prevalence of chronic obstructive pulmonary disease in rural women of Tamilnadu: implications for refining disease burden assessments attributable to household biomass combustion
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DOI：
10.3402/gha.v4i0.7226
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发表时间：
2011-01-01
影响因子：
2.6
通讯作者：
Subhashini, Arcot S.
中科院分区：
文献类型：
--
作者：
Johnson, Priscilla;Balakrishnan, Kalpana;Subhashini, Arcot S.
背景：慢性阻塞性肺疾病（COPD）是全球第13大疾病负担原因，预计到2020年将升至第5位。尽管吸烟被认为是最重要的危险因素，但生物质燃料燃烧对慢性阻塞性肺病有显著的促进作用。由于长期接触生物质燃料烟雾，发展中国家的农村妇女在这一负担中所占比例最大。尽管有相当有力的证据表明COPD与生物质烟雾暴露之间存在关联，但关于这些人群中COPD背景患病率的信息有限。目的：本研究旨在评估印度南部泰米尔纳德邦Tiruvallur地区非吸烟农村妇女COPD患病率及其相关因素。设计：这项横断面研究于2007年1月至5月期间在印度南部泰米尔纳德邦蒂鲁瓦卢尔地区45个农村的900名30岁以上的不吸烟妇女中进行。COPD评估采用临床检查和肺活量测定相结合的方法进行。进行了Logistic回归分析，以检验COPD与使用生物质烹饪之间的关系。采用R软件进行统计分析。结果：本研究中COPD的总患病率为2.44% （95% CI: 1.43-3.45）。生物质燃料使用者的COPD患病率高于清洁燃料使用者（2.5 vs. 2%）， （OR: 1.24; 95% CI: 0.36-6.64），每天在厨房做饭的妇女的COPD患病率是前者的两倍（3%）。使用固体燃料与COPD的高风险相关，尽管在本研究中没有得到统计学上显著的结果。结论：本研究得出的估算值将为不断增长的农村妇女COPD患病率可用信息数据库做出重大贡献。此外，通过同时进行室内空气污染测量，有可能进一步确定生物质利用与慢性阻塞性肺病患病率之间的关系，并改进现有的可归因疾病负担估计。
Background: Chronic obstructive pulmonary disease (COPD) is the 13th leading cause of burden of disease worldwide and is expected to become 5th by 2020. Biomass fuel combustion significantly contributes to COPD, although smoking is recognized as the most important risk factor. Rural women in developing countries bear the largest share of this burden resulting from chronic exposures to biomass fuel smoke. Although there is considerable strength of evidence for the association between COPD and biomass smoke exposure, limited information is available on the background prevalence of COPD in these populations.Objective: This study was conducted to estimate the prevalence of COPD and its associated factors among non-smoking rural women in Tiruvallur district of Tamilnadu in Southern India.Design: This cross-sectional study was conducted among 900 non-smoking women aged above 30 years, from 45 rural villages of Tiruvallur district of Tamilnadu in Southern India in the period between January and May 2007. COPD assessments were done using a combination of clinical examination and spirometry. Logistic regression analysis was performed to examine the association between COPD and use of biomass for cooking. R software was used for statistical analysis.Results: The overall prevalence of COPD in this study was found to be 2.44% (95% CI: 1.43-3.45). COPD prevalence was higher in biomass fuel users than the clean fuel users 2.5 vs. 2%, (OR: 1.24; 95% CI: 0.36-6.64) and it was two times higher (3%) in women who spend >2 hours/day in the kitchen involved in cooking. Use of solid fuel was associated with higher risk for COPD, although no statistically significant results were obtained in this study.Conclusion: The estimates generated in this study will contribute significantly to the growing database of available information on COPD prevalence in rural women. Moreover, with concomitant indoor air pollution measurements, it may be possible to increase the resolution of the association between biomass use and COPD prevalence and refine available attributable burden of disease estimates.