Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.
Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.
复制标题
粪便毒素浓度无法区分 3 岁以下儿童的艰难梭菌感染和定植。
DOI：
10.1093/jpids/piac059
复制
发表时间：
2022
影响因子：
3.2
通讯作者：
Pollock,NiraR
中科院分区：
文献类型：
--
作者：
Sandora,ThomasJ;Williams,DavidN;Daugherty,Kaitlyn;Geer,Christine;Cuddemi,Christine;Kociolek,LarryK;Chen,Xinhua;Xu,Hua;Savage,TimothyJ;Banz,Alice;Garey,KevinW;Gonzales-Luna,AnneJ;Kelly,CiaránP;Pollock,NiraR
在一项前瞻性队列研究中，对艰难梭菌核酸扩增试验阳性的3岁以下腹泻和非腹泻儿童的粪便进行了超灵敏定量毒素检测。在37例病例和46例对照中，毒素浓度分布基本重叠。毒素浓度本身并不能阻止C。很难在幼儿中从定植中感染。
In a prospective cohort study, stools from children <3 years with and without diarrhea who wereClostridioides difficilenucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguishC. difficileinfection from colonization in young children.