Animal Models of Disease
Animal Models of Disease
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疾病动物模型
DOI：
10.1002/0471141755.ph0500s28
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发表时间：
2005
影响因子：
--
通讯作者：
R. Porsolt
中科院分区：
文献类型：
--
作者：
R. Porsolt
In their purest sense, animal models represent an attempt to imitate the pathologies associated with human disease states in a preclinical setting. In some instances, as with the spontaneously hypertensive rat (SHR) model of hypertension, there is good correlation with therapeutic activity in humans. In others, such as amphetamine-induced hyperactivity in the rat, used to assess potential antipsychotic activity, the model is mechanism-based, merely reflecting the ability of a new compound to block dopamine-receptor function. In that instance, the use of the animal model to develop new drugs for treating schizophrenia has resulted in drugs with the same limitations as existing drugs. With the advent of transgenic animals whose genomes have been manipulated to underexpress a target gene or express it in a defective, nonfunctional form—“knockout” models—it is now possible to assess the role of a specific gene, and therefore potentially develop an animal model of a given human disease state once the underlying gene is identified.
