The dynamics of word retrieval in major depression
The dynamics of word retrieval in major depression
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DOI：
10.1177/0004867412465124
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发表时间：
2013-03-01
影响因子：
4.6
通讯作者：
Alsop, Brent
中科院分区：
文献类型：
--
作者：
Douglas, Katie M.;Porter, Richard J.;Alsop, Brent
目的：抑郁症患者自传体记忆中特定事件的提取障碍是常见的。然而，目前还不清楚是否在检索过程中的障碍是一个普遍的特征，抑郁症或仅限于回忆的个人memors.This研究探讨了时间进程的检索词从semantic memory.Method：字母流畅性测试进行了65例住院抑郁症和50名健康对照。一个双参数模型被拟合到代表90秒内单词产生的衰减曲线。其中一个参数N是对回答者在无限时间内所能产生的总字数的估计。另一个，tau，是平均值的第一个字产生的时间和每个随后的world.Results之间的差异：有证据表明，在检索词从长期记忆中抑郁症患者的赤字。两组之间的显著差异表明，即使给予一段较长的时间来弥补可能的缓慢反应，抑郁组也不会像控制组那样检索到那么多的单词。检索失败不能仅仅归因于认知减慢或抗抑郁药物的影响。结论：结果延长了从自传体记忆中检索特定事件的过程中的赤字的发现，并表明记忆检索的普遍损害可能是重性抑郁症的特征。
Objective: Impairment in the retrieval of specific episodes from autobiographical memory is commonly observed in major depression. However, it is unclear whether impairment in retrieval processes is a general characteristic of major depression or is confined to the recollection of personal memories.This study examined the time course of the retrieval of words from semantic memory.Method: A letter fluency test was administered to 65 inpatients with major depression and 50 healthy controls. A two-parameter model was fit to the decay curve representing the production of words over a 90-second period. One parameter, N, is an estimate of the total number of words that would be generated if the respondent was given unlimited time. The other, tau, is the average of the difference in time between the first word generated and each subsequent word.Results: There was evidence of a deficit in the retrieval of words from long-term memory in depressed patients. The significant difference between groups suggested that even if given an extended period of time in which to respond to compensate for possible slowness, the depressed group would not retrieve as many words as the controls. The retrieval failure could not be attributed solely to cognitive slowing or the effects of antidepressant medication.Conclusions: The results extend findings of a deficit in the process of retrieving specific episodes from autobiographical memory and suggest that a generalised impairment in memory retrieval may be characteristic of major depression.