Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer.
Lymphatic Vessels, Inflammation, and Immunity in Skin Cancer.
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DOI：
10.1158/2159-8290.cd-15-0023
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发表时间：
2016-01
期刊：
影响因子：
28.2
通讯作者：
Coussens LM
中科院分区：
文献类型：
--
作者：
Lund AW;Medler TR;Leachman SA;Coussens LM
皮肤是一个高度有序的免疫器官，协调对外部损伤的快速反应，同时保持自身耐受性。在健康组织中，淋巴管排出液体并协调局部免疫反应;然而，环境因素诱导淋巴管功能障碍，导致淋巴停滞和局部免疫紊乱。这些相同的环境因素驱动了局部恶性肿瘤的形成，这些恶性肿瘤也受到局部炎症的影响。在此，我们讨论了支持淋巴管参与调节皮肤炎症和免疫的原则的临床和实验证据，是恶性肿瘤的重要贡献者，也是免疫治疗的潜在生物标志物和靶点。
Skin is a highly ordered immune organ that coordinates rapid responses to external insult while maintaining self-tolerance. In healthy tissue, lymphatic vessels drain fluid and coordinate local immune responses; however, environmental factors induce lymphatic vessel dysfunction, leading to lymph stasis and perturbed regional immunity. These same environmental factors drive the formation of local malignancies, which are also influenced by local inflammation. Herein, we discuss clinical and experimental evidence supporting the tenet that lymphatic vessels participate in regulation of cutaneous inflammation and immunity, are important contributors to malignancy and potential biomarkers and targets for immunotherapy.