The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration.
The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration.
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Hippo通路在心脏再生中的细胞自主和非细胞自主作用。
DOI：
10.1016/j.yjmcc.2022.04.018
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发表时间：
2022-05
影响因子：
5
通讯作者：
Shijie Liu;R. Li;James F. Martin
中科院分区：
文献类型：
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作者：
Shijie Liu;R. Li;James F. Martin
心肌细胞是分化的心肌细胞，具有极低的自我更新能力。因此，心血管疾病和损伤造成的心肌细胞损失不能得到有效的补充。最近的动物模型研究表明，诱导内源性心肌细胞增殖是心脏再生所必需的，抑制Hippo信号通路可以刺激心肌细胞增殖和心脏再生。越来越多的证据表明，心肌细胞的增殖需要一个由多种细胞类型组成的允许的微环境。在这篇综述中，我们总结了最近的研究，强调了河马途径如何通过细胞自主和非细胞自主机制来调节心脏再生。我们还讨论了最近在大型动物模型中进行的翻译研究，这些研究证明了以河马通路为靶点在心脏病治疗中的治疗潜力。
Cardiomyocytes are differentiated heart muscle cells with minimal self-renewal ability. Thus, loss of cardiomyocytes from cardiovascular disease and injury cannot be effectively replenished. Recent studies in animal models have indicated that induction of endogenous cardiomyocyte proliferation is essential for cardiac renewal and that inhibiting the Hippo signaling pathway can stimulate cardiomyocyte proliferation and heart regeneration. Increasing evidence has suggested that cardiomyocyte proliferation requires a permissive microenvironment that consists of multiple cell types. In this review, we summarize recent studies that highlight how the Hippo pathway regulates heart regeneration through cell-autonomous and non–cell-autonomous mechanisms. We also discuss recent translational studies in large animal models that demonstrate the therapeutic potential of targeting the Hippo pathway in the treatment of heart disease.