Prevalence of Medication Errors and the Associated Factors: A Prospective Observational Study Among Cancer Patients at Mbarara Regional Referral Hospital.
Prevalence of Medication Errors and the Associated Factors: A Prospective Observational Study Among Cancer Patients at Mbarara Regional Referral Hospital.
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DOI：
10.2147/cmar.s307001
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发表时间：
2021
影响因子：
3.3
通讯作者：
Atukunda E
中科院分区：
文献类型：
--
作者：
Dorothy A;Yadesa TM;Atukunda E
用药差错是现代医学实践中最常见的医疗差错之一。在接受化疗的癌症患者中，由于抗癌药物的治疗指标狭窄、给药复杂以及毒性，用药错误可能会造成潜在的危害。本研究旨在确定癌症患者用药错误的发生率及相关因素。该研究是在乌干达西南部姆巴拉拉地区转诊医院癌症部门进行的一项前瞻性观察研究。该研究包括110名接受化疗的成人和儿童。该研究从2020年1月到5月进行了为期5个月的研究。使用检查表收集患者、药物和疾病信息，以确定处方、转录、配药和给药错误。在110名参与者中，52人（47.3%）总共经历了78次用药错误（MEs）。其中处方错误33例（42.31%），给药错误29例（37.18%），转录错误9例（11.54%），调剂错误7例（8.97%）。在与用药错误相关因素的调整后logistic回归中，城市居民（aOR, 4.59; 95% CI, 1.08, 19.53, p= 0.039）和受教育程度为中等水平的参与者（aOR, 10.51; 95% CI, 1.43, 77.14, p= 0.021）发生用药错误的风险显著更高。与其他类型的化疗相比，接受烷基化剂治疗的参与者（aOR, 2.87; 95% CI, 1.07, 7.72, p= 0.036）出现用药错误的风险更高。在姆巴拉拉地区转诊医院，癌症患者用药错误的发生率很高。处方错误是最常见的错误类型，其次是管理错误，分配错误是最不常见的。居住地、文化程度、烷基化剂化疗与用药错误发生率显著相关。
Medication error is one of the most common medical errors in the practice of modern medicine. Among cancer patients receiving chemotherapy, medication errors can be potentially harmful given the narrow therapeutic index, complex dosing, and toxic nature of anti-cancer drugs. This study aimed to determine the incidence and factors associated with medication errors among cancer patients. The study was a prospective observational study carried out at the cancer unit of Mbarara Regional Referral Hospital, Southwestern Uganda. The study included 110 participants, both adults and children receiving chemotherapy. The study was carried out for a period of five months from January to May 2020. A checklist was used to collect patient, medication, and disease information to identify the prescription, transcription, dispensing, and administration errors. Of the 110 participants, 52 (47.3%) experienced a total of 78 medication errors (MEs). Of these, 33 (42.31%) were prescription errors, 29 (37.18%) administration errors, 9 (11.54%) transcription errors, and 7 (8.97%) dispensing errors. In the adjusted logistic regression of factors associated with medication errors, urban residents (aOR, 4.59; 95% CI, 1.08, 19.53, p= 0.039) and educated participants (at secondary level) (aOR, 10.51; 95% CI, 1.43, 77.14, p= 0.021) had a significantly higher risk of experiencing medication errors. Participants treated with alkylating agents (aOR, 2.87; 95% CI, 1.07, 7.72, p= 0.036) had a greater risk of experiencing medication errors when compared to other classes of chemotherapy. The incidence of medication errors among cancer patients was high in Mbarara Regional Referral Hospital. Prescription errors were the most common type of error followed by administration errors, and dispensing errors were the least common. Residence, education level, and alkylating agent chemotherapy were significantly associated with occurrence of medication errors.