Killing of E-coli cells by E group nuclease colicins
Killing of E-coli cells by E group nuclease colicins
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DOI：
10.1016/s0300-9084(02)01450-5
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发表时间：
2002-05-01
期刊：
影响因子：
3.9
通讯作者：
Kleanthous, C
中科院分区：
文献类型：
--
作者：
James, R;Penfold, CN;Kleanthous, C
大肠杆菌素E9的核酸内切酶结构域跨过外膜、周质空间和细胞质膜到达大肠杆菌细胞的细胞质，导致DNA降解和细胞死亡的过程是原核生物学中的独特事件。尽管关于 BtuB 外膜受体的作用以及易位过程所必需的周质 Tol 蛋白的作用已有大量信息，但大肠杆菌素 E9 与这些蛋白之间相互作用的确切性质仍有待阐明。在这篇综述中，我们考虑了我们目前对该过程中关键事件的理解，重点关注有关受体结合、易位和细胞毒性机制的最新发现。 (C) 2002 Societe francaise de biochimie et biologic molecularaire / Editions scientifiques et Medicales Elsevier SAS。版权所有。
The process by which the endonuclease domain of colicin E9 is translocated across the outer membrane, the periplasmic space and the cytoplasmic membrane to reach the cytoplasm of E. coli cells, resulting in DNA degradation and cell death, is a unique event in prokaryotic biology. Although considerable information is known about the role of the BtuB outer membrane receptor, as well as the mostly periplasmic Tol proteins that are essential for the translocation process, the precise nature of the interactions between colicin E9 and these proteins remains to be elucidated. In this review, we consider our current understanding of the key events in this process, concentrating on recent findings concerning receptor-binding, translocation and the mechanism of cytotoxicity. (C) 2002 Societe francaise de biochimie et biologic moleculaire / Editions scientifiques et medicales Elsevier SAS. All rights reserved.