Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-α and interferon-γ in preterm labor
Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-α and interferon-γ in preterm labor
复制标题
DOI：
10.1034/j.1600-0412.2003.00156.x
复制
发表时间：
2003-06-01
影响因子：
4.3
通讯作者：
Nabri, OA
中科院分区：
文献类型：
--
作者：
Bahar, AM;Ghalib, HW;Nabri, OA
背景资料。目的探讨孕妇血清IL-6、IL-8、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)水平升高与早产的关系，以及检测这些细胞因子是否可用于早产早期宫内感染的检测。横断面研究：早产妇女77例，健康早产妇女47例，足月分娩妇女19例。采用酶联免疫吸附试验(EL ISA)检测血清细胞因子水平。对分娩中妇女的新生儿进行了跟踪调查，以寻找感染的证据。组间比较采用方差分析、t检验和卡方检验。不同组间测定的所有细胞因子浓度均无显著差异。早产胎膜破裂者与胎膜完整者细胞因子浓度差异无统计学意义。细菌培养阳性的新生儿与细菌培养阴性的新生儿在细胞因子浓度上也没有差异。IL-6、IL-8与肿瘤坏死因子α呈正相关。与正常对照组相比，早产妇女血清IL-6、IL-8和肿瘤坏死因子-α水平并未升高。孕妇血清中这些细胞因子的测定对于检测早产早期胎儿感染的有效性还存在疑问，但这还需要进一步的评估。
Background. To find out whether preterm labor is associated with raised maternal serum concentrations of interleukin (IL)-6, IL-8, tumor necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) and whether the measurement of these cytokines can be used to detect early intrauterine infection in preterm labor.Methods. Cross-sectional study: 77 women in preterm labor, 47 controls of healthy preterm women not in labor and 19 women in term labor. The serum cytokines levels were measured by enzyme-linked immunosorbent assay (ELISA). The newborns of women who were in labor were followed up for evidence of infection. Differences between groups were tested using analysis of variance, Student's t-test and chi(2)-test.Results. There was no significant difference in the concentration of all the cytokines measured between the different groups. No statistical difference was found in the concentration of the cytokines between women in preterm labor with ruptured membranes and those with intact membranes. There was also no difference found in the concentration of cytokines between women whose newborns had positive bacterial culture and those with negative culture. There was a positive correlation between the concentrations of IL-6, IL-8 and TNF-alpha.Conclusion. Serum levels of interleukin-6, interleukin-8 and tumor necrosis factor-alpha were not increased in preterm labor compared to normal control women. There is doubt regarding the usefulness of maternal serum measurement of these cytokines for the detection of early fetal infection in preterm labor, but this needs further evaluation.