Technologies and Challenges in Proteomic Analysis of Protein S-acylation.
Technologies and Challenges in Proteomic Analysis of Protein S-acylation.
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DOI：
10.4172/jpb.1000327
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发表时间：
2014-09
期刊：
影响因子：
--
通讯作者：
Yang W
中科院分区：
文献类型：
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作者：
Zhou B;An M;Freeman MR;Yang W
蛋白质S-酰化（也称为棕榈酰化）是一种普遍的翻译后修饰，其在调节蛋白质运输、定位、稳定性、活性和复合物形成中起关键作用。在过去的十年里，蛋白质S-酰化的研究取得了巨大的进展，这主要归功于新的S-酰基蛋白质组学技术的发展。在这篇综述中，我们总结了目前的S-酰基蛋白质组学的方法，批判性地回顾已发表的S-酰基蛋白质组学研究，并展望了新兴的S-酰基蛋白质组学领域的未来发展方向。新兴的S-酰基蛋白质组学技术有望揭示这种独特的翻译后修饰，并促进新的疾病机制，生物标志物和治疗靶点的发现。
Protein S-acylation (also called palmitoylation) is a pervasive post-translational modification that plays critical roles in regulating protein trafficking, localization, stability, activity, and complex formation. The past decade has witnessed tremendous advances in the study of protein S-acylation, largely owing to the development of novel S-acylproteomics technologies. In this review, we summarize current S-acylproteomics approaches, critically review published S-acylproteomics studies, and envision future directions for the burgeoning S-acylproteomics field. Emerging S-acylproteomics technologies promise to shed new light on this distinct post-translational modification and facilitate the discovery of new disease mechanisms, biomarkers, and therapeutic targets.