The comparative pathobiology of atherosclerosis and restenosis
The comparative pathobiology of atherosclerosis and restenosis
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DOI：
10.1016/s0002-9149(00)01094-8
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发表时间：
2000-08-24
影响因子：
2.8
通讯作者：
Rogers, C
中科院分区：
文献类型：
--
作者：
Orford, JL;Selwyn, AP;Rogers, C
经皮冠状动脉介入治疗（PCI）在冠状动脉疾病患者的治疗中发挥着越来越重要的作用。然而，这些重要的手术因大量患者的再狭窄而变得复杂。动脉粥样硬化的病理学包括脂质、内皮、循环和组织炎症细胞、血小板和血管平滑肌细胞之间复杂的相互作用。PCI 的机械和细胞后果叠加在动脉粥样硬化的异常基质上，导致了一种特征性和独特的特征。 病理生物学引发并维持再狭窄，清楚地了解动脉粥样硬化和再狭窄之间的显着差异将为制定始终解决这两个问题的治疗计划提供合理的基础。本文回顾和对比了动脉粥样硬化和再狭窄的病理学，并比较了这些不同实体的机制和时程。 (C) 2000 年，Medica, Inc. 摘录。
Percutaneous coronary interventions (PCIs) play an increasingly important role in the management of patients with coronary artery disease. However, these important procedures are complicated by restenosis in a sizeable number of patients, The pathobiology of atherosclerosis comprises a complex interaction among lipids, the endothelium, circulating and tissue inflammatory cells, platelets, and vascular smooth muscle cells, The superimposition of the mechanical and cellular consequences of PCIs on the abnormal substrate of atherosclerosis leads to a characteristic and distinct pathobiology that initiates and perpetuates restenosis, A clear understanding of the significant differences between atherosclerosis and restenosis will provide a rational basis for developing treatment plans hat always address both problems. This article reviews and contrasts the pathobiology of atherosclerosis and restenosis and compares the mechanisms and time-course of these distinct entities. (C) 2000 by Excerpta of Medica, Inc.