Terminal transferase as a predictor of initial responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia: a co-operative study.
Terminal transferase as a predictor of initial responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia: a co-operative study.
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末端转移酶作为急变型慢性粒细胞白血病对长春新碱和泼尼松初始反应的预测因子：一项合作研究。
DOI：
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发表时间：
1978
影响因子：
158.5
通讯作者：
R. Mccaffrey
中科院分区：
文献类型：
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作者：
S. Marks;D. Baltimore;R. Mccaffrey
我们进行了一项前瞻性试验，以评估末端脱氧核苷酸转移酶活性作为22例费城染色体阳性的慢性原始细胞性髓性白血病患者对长春新碱和泼尼松反应性的预测因子。13例转移酶阳性，9例阴性。9例阴性患者无反应，而13例阳性患者中有8例（P = 0.004）的反应是外周血原始细胞完全清除，正常骨髓细胞结构恢复，原始细胞低于5%。在50岁以下的转移酶阳性患者中，应答率为78%。成淋巴细胞与成髓细胞）与反应性或末端转移酶活性均无显著相关性。本研究的结果表明，对长春新碱和泼尼松的反应性在急变型慢性粒细胞白血病仅限于患者的白血病细胞是转移酶阳性。
We undertook a prospective trial to evaluate terminal deoxynucleotidyl transferase activity as a predictor of responsiveness to vincristine and prednisone in 22 Philadelphia-chromosome-positive patients with blastic chronic myelogenous leukemia. Thirteen patients were transferase positive, and nine negative. None of the nine negative patients responded, whereas eight of the 13 positive (P = 0.004) responded with complete clearing of peripheral blood blast cells and a return of normal marrow cellularity with less than 5 per cent blast cells. Among transferase-positive patients under 50 years of age the response rate was 78 per cent. Blast-cell morphology (i.e., lymphoblastic versus myeloblastic) had no significant correlation with either responsiveness or terminal transferase activity. The results of this study suggest that responsiveness to vincristine and prednisone in blastic chronic myelogenous leukemia is confined to patients whose leukemic cells are transferase positive.