Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.
Non-canonical roles of apoptotic and DNA double-strand break repair factors in mediating cellular response to ionizing radiation.
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DOI：
10.1080/09553002.2021.1948139
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发表时间：
2023
影响因子：
2.6
通讯作者：
Li CY
中科院分区：
文献类型：
--
作者：
Li CY
为了解细胞凋亡和DNA双链断裂修复因子在各种生物学过程中，特别是在细胞对放射治疗的反应中的非典型作用，提供最新进展。凋亡的半胱氨酸天冬氨酸酶通常被认为是不想要的或受损的细胞或组织的“刽子手”。然而，最近的研究表明，它们在许多生物过程中扮演着多种额外的、往往是违反直觉的角色。同样，DNA双链断裂(DSB)修复因子也被发现在修复受损DNA之外发挥着意想不到的作用。在这篇综述中，我将总结关于凋亡和DSB修复因子在不同的生物和病理过程中的非典型作用的主要发现，这些过程包括辐射诱导的遗传不稳定和致癌、伤口愈合和组织再生、诱导多能干细胞诱导、自发和随机产生癌症干细胞以及癌症免疫治疗。我相信这些发现将在这个令人兴奋和快速发展的领域带来更多的研究。
To provide an updated summary of recent advances in our understanding of the non-canonical roles of apoptotic and DNA double-strand break repair factors in various biological processes, especially in the cellular response to radiotherapy. Apoptotic caspases are usually considered as “executioners’’ of unwanted or damaged cells or tissues. However, recent studies indicated they play multiple additional, often counterintuitive roles in many biological processes. Similarly, DNA double-strand break (DSB) repair factors were also found to play unexpected roles beyond repairing damaged DNA. In this review, I will summarize key findings on the non-canonical roles of apoptotic and DSB repair factors in disparate biological and pathological processes such as radiation-induced genetic instability and carcinogenesis, wound healing and tissue regeneration, induced pluripotent stem cell induction, spontaneous and stochastic generation of cancer stem cells, and cancer immunotherapy. I believe these findings will usher in more studies in this exciting and rapidly evolving field.