Comparative morphine pharmacokinetics following sublingual, intramuscular, and oral administration in patients with cancer.
Comparative morphine pharmacokinetics following sublingual, intramuscular, and oral administration in patients with cancer.
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癌症患者舌下、肌内和口服给药后吗啡药代动力学的比较。
DOI：
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
M. Ames
中科院分区：
文献类型：
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作者：
T. Davis;A. Miser;C. Loprinzi;J. S. Kaur;N. Burnham;A. M. Dose;M. Ames
以前的文献报道表明，与口服吗啡相比，舌下给药硫酸吗啡可提高药物的生物利用度。为了进一步研究这种可能性，我们研究了6名癌症患者，他们都通过肌肉注射、口服和舌下途径接受了10mg剂量的硫酸吗啡。与口服给药相比，药代动力学分析未能显示舌下给药的优势。肌内给药后吗啡的生物利用度明显优于口服和舌下给药。
Previous literature reports have suggested that sublingually administered morphine sulfate results in an improved bioavailability of the drug when compared to orally administered morphine. To investigate this possibility further, we studied six cancer patients all of whom received 10 mg doses of morphine sulfate by intramuscular, oral and sublingual routes. Pharmacokinetic analyses failed to suggest an advantage of sublingual administration when compared with oral dosing. Bioavailability of morphine following intramuscular administration appeared superior to both oral and sublingual routes.
血浆和脑脊液提取前后吗啡放射免疫测定的特异性。
影响因子：
3.8
作者：
Grabinski,PY;Kaiko,RF;Walsh,TD;Foley,KM;Houde,RW
通讯作者：
Houde,RW