Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.
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DOI：
10.1371/journal.pone.0015230
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发表时间：
2010-12-16
期刊：
影响因子：
3.7
通讯作者：
De Felice FG
中科院分区：
文献类型：
--
作者：
Saraiva LM;Seixas da Silva GS;Galina A;da-Silva WS;Klein WL;Ferreira ST;De Felice FG
Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and preventing apoptosis in neurons and other cell types. Brain isozyme HKI is mainly associated with mitochondria and HK release from mitochondria causes a significant decrease in enzyme activity and triggers oxidative damage. We here investigated the relationship between Aβ-induced oxidative stress and HK activity. We found that Aβ triggered HKI detachment from mitochondria decreasing HKI activity in cortical neurons. Aβ oligomers further impair energy metabolism by decreasing neuronal ATP levels. Aβ-induced HKI cellular redistribution was accompanied by excessive ROS generation and neuronal death. 2-deoxyglucose blocked Aβ-induced oxidative stress and neuronal death. Results suggest that Aβ-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in AD.
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影响因子：
3.3
作者：
Bigl, M;Apelt, J;Schliebs, R
通讯作者：
Schliebs, R
DOI：
10.1007/bf02815006
发表时间：
1996-10-01
期刊：
MOLECULAR AND CHEMICAL NEUROPATHOLOGY
影响因子：
--
作者：
Baum, L;Hansen, L;Saitoh, T
通讯作者：
Saitoh, T
影响因子：
4.8
作者：
De Felice, Fernanda G.;Velasco, Pauline T.;Klein, William L.
通讯作者：
Klein, William L.
影响因子：
4.1
作者：
Andersson, CX;Fernandez-Rodriguez, J;Hansson, GC
通讯作者：
Hansson, GC
DOI：
10.1073/pnas.95.11.6448
发表时间：
1998-05-26
影响因子：
11.1
作者：
Lambert, MP;Barlow, AK;Klein, WL
通讯作者：
Klein, WL