Natural killer cell immunotherapy for cancer: a new hope
Natural killer cell immunotherapy for cancer: a new hope
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DOI：
10.1080/14653240802648181
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发表时间：
2008-01-01
期刊：
影响因子：
4.5
通讯作者：
Childs, R. W.
中科院分区：
文献类型：
--
作者：
Srivastava, S.;Lundqvist, A.;Childs, R. W.
最近，我们对 NK 细胞在介导先天宿主免疫反应中的作用有了实质性的了解。尽管人们早已知道 NK 细胞可以介导抗原非依赖性肿瘤细胞毒性，但基于 NK 细胞的免疫疗法的治疗潜力尚未被认识到。操纵抑制性和激活性 NK 受体信号之间的平衡、肿瘤靶细胞对 NK 细胞介导的细胞凋亡的敏感性以及 NK 细胞受体生物学的最新发现，都推动了转化研究，从而引发了临床试验，研究了许多增强 NK 细胞毒性对人类恶性肿瘤的新方法。
Recently there has been a substantial gain in our understanding of the role NK-cells play in mediating innate host immune responses. Although NK cells have long been known to mediate antigen independent tumor cytotoxity, the therapeutic potential of NK cell-based immunotherapy has yet to be realized. Manipulating the balance between inhibitory and activating NK receptor signals, sensitization of tumor target cells to NK cell-mediated apoptosis, and recent discoveries in NK-cell receptor biology have fueled translational research that has led to clinical trials investigating a number of novel methods to potentiate NK cytotoxicity against human malignancies.