NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN
NORTRIPTYLINE AND ANTIPYRINE CLEARANCE IN RELATION TO DEBRISOQUINE HYDROXYLATION IN MAN
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DOI：
10.1016/0024-3205(80)90642-6
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发表时间：
1980-01-01
期刊：
影响因子：
6.1
通讯作者：
SJOQVIST, F
中科院分区：
文献类型：
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作者：
BERTILSSON, L;EICHELBAUM, M;SJOQVIST, F
健康人类志愿者 (8) 具有广泛的羟基化异喹啉（一种受多态性遗传控制的代谢反应）的能力，被给予单剂量的去甲替林和安替比林。个体羟化异喹啉和去甲替林的能力（以药物的血浆清除率来衡量）之间存在密切相关性（Spearman rs = 0.83；P = 0.01）。这 2 个苄基羟基化是由相似（即使不相同）的遗传因素控制的。与去甲替林相反，安替比林的清除率（在唾液中评估）与羟基化异喹啉的能力不呈正相关。
Healthy human volunteers (8) with a broad range in their ability to hydroxylate debrisoquine, a metabolic reaction which is under polymorphic genetic control, were given single oral doses of nortriptyline and antipyrine. There was a close correlation between an individual''s ability to hydroxylate debrisoquine and nortriptyline (measured as plasma clearance of the drug) (Spearman rs = 0.83; P = 0.01). These 2 benzylic hydroxylations are controlled by similar if not identical genetic factors. In contrast to nortriptyline the clearance of antipyrine (assessed in saliva) was not positively related to the ability to hydroxylate debrisoquine.