Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans
Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans
复制标题
人类逐渐寒冷暴露过程中多器官对非颤抖和颤抖产热和血管反应的贡献
DOI：
10.1007/s00421-020-04496-1
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发表时间：
2020
影响因子：
3
通讯作者：
Saito Masayuki
中科院分区：
文献类型：
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作者：
Wakabayashi Hitoshi;Matsumoto Kentaro;Kobori Yusuke;Ebara Tasuku;Matsushita Mami;Kameya Toshimitsu;Maeda Takafumi;Saito Masayuki
目的人类棕色脂肪组织（BAT）是非颤抖性产热（NST）中重要的热效应器，尽管BAT的活性存在个体差异。我们假设，人类与BAT少将有更多的贡献，从骨骼肌（SM）NST或更早的颤抖发作和更大的血管收缩，以弥补BAT介导的thermogenes.MethodsEighteen男性参加了这项研究。研究了它们的BAT活性和可检测体积。进行逐渐冷暴露以在18.6 °C下诱导NST并在11.6 °C下引发寒战。结果BAT体积与代谢产热在轻度寒冷期相对于基线的变化显著相关（NST;r= 0. 562，P <0. 05），但与寒战起始期（NST+ST）无相关性。SM质量与基线代谢产热相关（Mbase;r= 0.839，P < 0.01），而与NST或NST + ST无相关性。BAT体积与18.6 °C暴露期结束时的治疗呈正相关（r= 0.586，P < 0.05），与寒战发作时间呈正相关（r= 0.553，P < 0.05）。18.6 °C暴露结束时的皮肤血流量、平均皮肤温度、前臂和手指皮肤温差与NST或BAT体积均无相关性。值得注意的是，具有较少BAT体积的较低Trein个体诱导较早的寒战发作以抵消较少的NST。而代谢和血管反应之间没有相关性。
PurposeHuman brown adipose tissue (BAT) is known to be a significant thermoeffector in non-shivering thermogenesis (NST), albeit with individual variations in the BAT activity. We hypothesized that humans with less BAT would have more contribution from the skeletal muscle (SM) to NST or earlier shivering onset and greater vasoconstriction to compensate for less BAT-mediated thermogenesis.MethodsEighteen males participated in this study. Their BAT activity and detectable volume were investigated. A gradual cold exposure was conducted for inducing NST at 18.6 °C and initiating shivering at 11.6 °C. The energy expenditure, electromyograph of the pectoralis major, skin blood flow, and rectal (Tre) and skin temperatures were evaluated.ResultsBAT volume significantly correlated with the change in metabolic heat production during mild cold phase relative to baseline (NST;r= 0.562,P< 0.05), but not with shivering initiation phase (NST+ST). SM mass correlated with baseline metabolic heat production (Mbase;r= 0.839,P< 0.01) but not withNSTorNST+ST. A positive correlation was noted between BAT volume andTreat the end of the 18.6 °C exposure period (r= 0.586,P< 0.05), which positively correlated with shivering onset time (r= 0.553,P< 0.05). The skin blood flow, mean skin temperature, and forearm and finger skin temperature difference at the end of the 18.6 °C exposure period did not correlate withNSTor BAT volume.ConclusionBAT volume positively correlated withNST. Notably, lowerTrein individuals with less BAT volume induced earlier shivering onset for offsetting the lessNST. Whereas, no correlation between metabolic and vasomotor responses was observed.