Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men
Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men
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DOI：
10.1089/apc.2006.0150
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发表时间：
2007-07-01
影响因子：
4.9
通讯作者：
Klein, Robert S.
中科院分区：
文献类型：
--
作者：
Floris-Moore, Michelle;Howard, Andrea A.;Klein, Robert S.
心血管风险增加与HIV感染和联合抗逆转录病毒治疗有关，但在HIV感染人群中，丙型肝炎病毒（FICV）状态对心血管风险指数的影响尚未进行常规评估。本研究的目的是分析老年男性中HCV、HIV和联合抗逆转录病毒治疗与血脂水平和C反应蛋白（CRP）的关系。在一项横断面研究中，我们测量了108名HIV感染者和74名HIV未感染的高危老年男性的空腹总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯和高敏CRP血清水平。110名男性（60%）可检测到HCV RNA，HIV状态无差异（p = 0.25）。大多数（88%）丙型肝炎病毒感染男性有注射吸毒史。在所有男性中，HCV感染与较低的总胆固醇（p < 0.001）、LDL-C（p < 0.001）、甘油三酯（p = 0.01）和CRP（p < 0.001）独立相关。在HIV感染的男性中，HCV感染与总胆固醇（p < 0.001）、LDL-C（p < 0.001）和CRP（p = 0.004）降低相关。在接受蛋白酶抑制剂（PI）（p = 0.02）和非P1联合抗逆转录病毒治疗（p = 0.02）的男性中，FICV感染与甘油三酯降低相关，但在抗逆转录病毒初治男性中则无关。这些研究结果表明，较低的血脂和CRP水平与丙型肝炎病毒感染的关联，并建议FICV状态应评估为一个重要的相关性的心血管危险因素的研究中，老年男性与艾滋病毒或有风险的。
Increased cardiovascular risk has been linked to HIV infection and combination antiretroviral therapy, but the impact of hepatitis C virus (FICV) status on indices of cardiovascular risk has not been routinely assessed in the HIV-infected population. The objective of this study was to analyze associations of HCV, HIV, and combination antiretroviral therapy with lipid levels and C-reactive protein (CRP) among older men. We measured fasting total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride, and high-sensitivity CRP serum levels in a cross-sectional study of 108 HIV-infected and 74 HIV-uninfected at-risk older men. One hundred ten men (60%) had detectable HCV RNA, with no difference by HIV status (p = 0.25). The majority (88%) of men with HCV infection had a history of injection drug use. Among all men, HCV infection was independently associated with lower total cholesterol (p < 0.001), LDL-C (p < 0.001), triglycerides (p = 0.01), and CRP (p < 0.001). Among HIV-infected men, HCV infection was associated with lower total cholesterol (p < 0.001), LDL-C (p < 0.001), and CRP (p = 0.004). FICV infection was associated with lower triglycerides among men on protease inhibitors (PI) (p = 0.02) and nonP1 combination antiretroviral therapy (p = 0.02), but not among antiretroviral-na'fve men. These findings demonstrate an association of lower serum lipid and CRP levels with HCV infection and suggest that FICV status should be assessed as an important correlate of cardiovascular risk factors in studies of older men with or at risk for HIV.