Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges.
Juvenile onset depression alters cardiac autonomic balance in response to psychological and physical challenges.
复制标题
DOI：
10.1016/j.biopsycho.2015.07.003
复制
发表时间：
2015-09
影响因子：
2.6
通讯作者：
Kovacs M
中科院分区：
文献类型：
--
作者：
Bylsma LM;Yaroslavsky I;Rottenberg J;Jennings JR;George CJ;Kiss E;Kapornai K;Halas K;Dochnal R;Lefkovics E;Benák I;Baji I;Vetró Á;Kovacs M
心脏自主神经平衡（CAB）是副交感神经与交感神经激活的比率，被认为反映了面对环境挑战时的整体自主神经灵活性。然而，CAB尚未在抑郁症中进行检查。我们研究了CAB和其他生理变量的变化，在179名青少年发病抑郁症（JOD）和161名健康对照组的历史，在两个心理（无法解决的难题，悲伤的电影）和两个物理（握，前额冷加压）的挑战。在重复测量分析中，控制显示出预期的减少CAB的手柄和无法解决的难题，反映了交感神经相对于副交感神经激活的转变。相比之下，JOD青少年在两项任务中的CAB均较基线增加（ps<.05）。前额冷加压或悲伤电影任务没有发现任何影响，这表明CAB差异可能会出现在需要更大的注意力控制或持续努力的条件下。
Cardiac autonomic balance (CAB) indexes the ratio of parasympathetic to sympathetic activation, and is believed to reflect overall autonomic flexibility in the face of environmental challenges. However, CAB has not been examined in depression. We examined changes in CAB and other physiological variables in 179 youth with a history of juvenile onset depression (JOD) and 161 healthy controls, in response to two psychological (unsolvable puzzle, sad film) and two physical (handgrip, and forehead cold pressor) challenges. In repeated measures analyses, controls showed expected reductions in CAB for both the handgrip and unsolvable puzzle, reflecting a shift to sympathetic relative to parasympathetic activation. By contrast, JOD youth showed increased CAB from baseline for both tasks (ps<.05). No effects were found for the forehead cold pressor or sad film tasks, suggesting that CAB differences may arise under conditions requiring greater attentional control or sustained effort.