Association of IL-27 polymorphisms and cancer risk in Chinese population
Association of IL-27 polymorphisms and cancer risk in Chinese population
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DOI：
10.3109/10799893.2014.942465
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发表时间：
2015-04-01
影响因子：
2.8
通讯作者：
Wang, Weixing
中科院分区：
文献类型：
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作者：
Hu, Tiemin;Zhao, Hongyu;Wang, Weixing
许多遗传学研究试图将白细胞介素-27 （IL-27）多态性（rs153109、rs17855750和rs181206）与中国人群的癌症风险联系起来，包括胶质瘤、卵巢癌、肝细胞癌、结直肠癌、食管癌等。然而，结果是不确定的。本研究的目的是在荟萃分析中对任何关联进行更精确的估计。我们检索了PubMed数据库（截至2014年6月6日）关于IL-27多态性（rs153109、rs17855750和rs181206）与中国人群癌症风险的关联研究。采用随机/固定效应模型计算比值比（ORs）及其95%置信区间（ci）来评估相关性。敏感性分析用于评价结果的稳定性。采用贝格检验来测量发表偏倚。这项荟萃分析共纳入了6项符合条件的研究，涉及1684名患者和1837名对照。IL-27 rs153109多态性与中国人群癌症风险显著相关（GG vs AA: OR = 1.24, 95% CI = 1.00-1.54, p = 0.05）。然而，IL-27 rs17855750和rs181206多态性与中国人群癌症风险之间没有相关性。总之，本荟萃分析表明，IL-27 rs153109多态性与中国人群的癌症风险相关。
A number of genetic studies have attempted to link interleukin-27 (IL-27) polymorphisms (rs153109, rs17855750 and rs181206) to the risk of cancer in Chinese population, including glioma, ovarian cancer, hepatocellular carcinoma, colorectal cancer, esophageal cancer, etc. However, the results were inconclusive. The aim of this study is to derive a more precise estimation of any association in a meta-analysis. We searched the PubMed database (up to 6 June 2014) for studies regarding the association of IL-27 polymorphisms (rs153109, rs17855750 and rs181206) and the risk of cancer in Chinese population. Odds ratios (ORs) together with their 95% confidence intervals (CIs) were calculated by using random/fixed effect model to assess the association. Sensitivity analyses were used to assess the stability of the results. Begg's test was performed to measure publication bias. A total of six eligible studies with 1684 patients and 1837 controls were included in this meta-analysis. IL-27 rs153109 polymorphism was significantly associated with cancer risk in Chinese population (GG versus AA: OR = 1.24, 95% CI = 1.00-1.54, p = 0.05). However, there were no associations between IL-27 rs17855750 and rs181206 polymorphisms and cancer risk in Chinese population. In conclusion, this meta-analysis indicated that IL-27 rs153109 polymorphism was associated with cancer risk in Chinese population.