Effects of perinatal dioxin exposure on mirror neuron activity in 9-year-old children living in a hot spot of dioxin contamination in Vietnam
Effects of perinatal dioxin exposure on mirror neuron activity in 9-year-old children living in a hot spot of dioxin contamination in Vietnam
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围产期二恶英暴露对生活在越南二恶英污染热点地区的 9 岁儿童镜像神经元活动的影响
DOI：
10.1016/j.neuropsychologia.2021.108001
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发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
Nishijo Hisao
中科院分区：
文献类型：
--
作者：
Vu Hoa Thi;Nishijo Muneko;Pham Thao Ngoc;Pham-The Tai;Hoanh Luong Van;Tran Anh Hai;Tran Nghi Ngoc;Nishino Yoshikazu;Do Quyet;Nishijo Hisao
8年来，我们对生活在越南二恶英污染热点岘港空军基地附近的241对母婴进行了随访，并报道了围产期二恶英暴露对不同年龄儿童神经发育的影响。在本研究中，我们在出生9年后，通过分析执行和观察手部运动时的脑电图功率，研究围产期二恶英暴露对mu和theta节律的影响，这表明镜像神经元系统的活动。方法对岘港市出生队列155名9岁儿童（男86名，女69名）进行手电自由观察脑电图检查。出生1个月后测量母亲母乳中的二恶英水平，作为围产期二恶英暴露标记。执行或观察手部运动时的脑电图功率与观察弹跳球时的脑电图功率之比的对数变换用于评估镜像神经元的活动。结果暴露于高剂量TCDD的女孩在观察手部运动时，两脑半球θ波段的对数功率比显著升高（即功率减少较少）。然而，在男孩中，除TCDD外的二恶英同系物，包括hxcdd和几种PCDF同系物，导致θ波段对数功率比增加。特别是对于PCDF同系物，在4个暴露组中，最低组的对数功率比最低，且随着剂量的增加，对数功率比显著增加（即功率减少）。结论围生期接触TCDD可能影响儿童，特别是越南二恶英污染高发区女童的大脑镜像神经元系统，该系统在儿童社交情绪行为中起重要作用。
BackgroundFor 8 years, we have followed up a birth cohort comprising 241 mother-and-infant pairs living around the Da Nang airbase, a hot spot of dioxin contamination in Vietnam, and have reported the impacts of perinatal dioxin exposure on the neurodevelopment of children at various ages. In the present study, 9 years after birth, we investigated the effects of perinatal dioxin exposure on mu and theta rhythms by analyzing EEG power during the execution and observation of hand movements, which indicate mirror neuron system activity.MethodsOne hundred fifty-five 9-year-old children (86 boys and 69 girls) from the Da Nang birth cohort participated in the EEG examination with free viewing of hand movements. The dioxin levels in their mothers’ breast milk, measured 1 month after birth, were used as perinatal dioxin exposure markers. A log transform of the ratio of EEG power during execution or observation of the hand movements relative to the power during observation of a bouncing ball for theta and mu rhythms was used to evaluate mirror neuron activity.ResultsIn both brain hemispheres, the log power ratio in the theta band was significantly higher (i.e., less reduction of power) during observation of hand movements in girls exposed to high levels of TCDD. In boys, however, dioxin congeners other than TCDD, including HxCDDs and several PCDF congeners, contributed to increased log power ratios in the theta band. Particularly for PCDF congeners, the log power ratios in the lowest group among 4 exposure groups were lowest and significantly increased (i.e., decreasing reduction of power) with increasing dose.ConclusionPerinatal TCDD exposure may influence the mirror neuron system of the brain, which plays an important role for social-emotional behavior in children, particularly in girls living in a hot spot of dioxin contamination in Vietnam.