Regenerative capacity of skeletal muscle
Regenerative capacity of skeletal muscle
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DOI：
10.1097/01.wco.0000177382.62156.82
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发表时间：
2005-10-01
影响因子：
4.8
通讯作者：
Morgan, J
中科院分区：
文献类型：
--
作者：
Ehrhardt, J;Morgan, J
综述的目的是重点介绍近年来在骨骼肌再生领域取得的进展。最近的研究结果增加了我们对卫星细胞在其壁龛内对肌肉纤维的激活、卫星细胞衍生的肌肉前体细胞在骨骼肌再生中的贡献以及老年肌肉中卫星细胞功能的降低的理解。虽然其他干细胞，无论是来自或存在于骨骼肌或其他组织中的骨髓，确实有助于肌肉再生，但最近的研究强调，与卫星细胞再生骨骼肌的能力相比，这充其量是微不足道的。宿主肌肉环境的影响已被证明对骨骼肌再生有深远的影响。年龄和去神经有有害的影响，而某些类型的肌肉损伤有积极的影响。关于生长因子对体外肌肉细胞系和活体肌肉再生的影响的研究仍在继续。综述最近的工作集中在卫星细胞来源的肌肉前体细胞和其他干细胞对骨骼肌再生的贡献上。肌肉环境对驻留细胞和植入细胞的再生能力有着深刻的影响。肌肉再生可以通过使用最佳干细胞群和改变宿主肌肉环境来优化。
Purpose of review The aim of this review is to highlight advances in the field of skeletal muscle regeneration that have been made in the last year.Recent findings Studies have increased our understanding of the activation of satellite cells within their niche on the muscle fibre, the contribution of satellite cell-derived muscle precursor cells to skeletal muscle regeneration and the reduction of satellite cell function in old muscle. Although other stem cells, either bone marrow derived or present within skeletal muscle or other tissues, do contribute to muscle regeneration, recent studies have highlighted that this is at best minimal compared with the ability of satellite cells to regenerate skeletal muscle. The effect of the host muscle environment has been shown to have a profound effect on skeletal muscle regeneration. Age and denervation have a detrimental effect and certain types of muscle injury a positive effect. Work continues on the effect of growth factors on muscle cell lines in vitro and muscle regeneration in vivo.Summary Recent work has focused on the contribution of satellite-cell derived muscle precursor cells and other stem cells to skeletal muscle regeneration. The muscle environment has a profound effect on the regenerative capacity of resident and implanted cells. Muscle regeneration may be optimized by using the best stem cell population and by modifying the host muscle environment.