Navigation expertise and the human hippocampus: A structural brain imaging analysis
Navigation expertise and the human hippocampus: A structural brain imaging analysis
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DOI：
10.1002/hipo.10087
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发表时间：
2003-01-01
期刊：
影响因子：
3.5
通讯作者：
Burgess, N
中科院分区：
文献类型：
--
作者：
Maguire, EA;Spiers, HJ;Burgess, N
伦敦出租车司机后海马体的灰质体积大于年龄匹配的对照组，这种增加的大小与驾驶出租车的时间呈正相关（E.A. Maguire等人，2000. Proc Natl Acad Sci U S A 97：4398-4403）。这一变化表明，增加后海马灰质体积获得响应增加出租车驾驶经验，也许反映了他们的详细代表的城市。然而，另一种假设是，海马体积的差异与先天的导航专业知识有关，导致成为出租车司机的可能性增加。为了研究这种可能性，我们使用结构脑成像和基于体素的形态测量（VBM）来检查一组不是出租车司机的受试者。尽管这一组显示出广泛的导航专业知识，但专业知识与海马后部灰质体积（或者，实际上，整个大脑的灰质体积）之间没有关联。因此，未能找到海马体积和导航技能之间的关联表明，人类海马的结构差异反映了所获得的空间表示的使用细节和/或持续时间，而不是先天的导航技能本身。(C)2003 Wiley-Liss，Inc.
Grey matter volume in the posterior hippocampus of London taxi drivers is greater than in age-matched controls, and the size of this increase correlates positively with time spent taxi driving (E.A. Maguire et al., 2000. Proc Natl Acad Sci U S A 97: 4398-4403). This change suggests that increased posterior hippocampal grey matter volume is acquired in response to increased taxi driving experience, perhaps reflecting their detailed representation of the city. However, an alternate hypothesis is that the difference in hippocampal volume is instead associated with innate navigational expertise, leading to an increased likelihood of becoming a taxi driver. To investigate this possibility, we used structural brain imaging and voxel-based morphometry (VBM) to examine a group of subjects who were not taxi drivers. Despite this group showing a wide range of navigational expertise, there was no association between expertise and posterior hippocampal grey matter volume (or, indeed, grey matter volume throughout the brain). This failure to find an association between hippocampal volume and navigational expertise thus suggests that structural differences in the human hippocampus reflect the detail and/or duration of use of the spatial representation acquired, and not innate navigational expertise per se. (C) 2003 Wiley-Liss, Inc.