The "Swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of object-location memory in aged Tg2576 mice
The "Swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of object-location memory in aged Tg2576 mice
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DOI：
10.1037/0735-7044.121.6.1180
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发表时间：
2007-12-01
影响因子：
1.9
通讯作者：
Hale, Gemma
中科院分区：
文献类型：
--
作者：
Good, Mark A.;Hale, Gemma
老年 Tg2576 小鼠表现出海马形态和生理学异常，并且在空间导航任务中表现出行为缺陷，这与海马功能特性的缺陷相一致。然而，淀粉样前体蛋白（APPswe）的“瑞典”突变所破坏的空间表征的性质尚不清楚。为了表征 Tg2576 小鼠的记忆缺陷，使用自发物体探索范式来询问小鼠的空间和物体记忆。对于大小相当的物体阵列，16 个月大的 Tg2576 小鼠表现出正常的物体熟悉度/新奇效应，但当 2 个物体交换位置时，对物体位置的记忆受损（拓扑变换；实验 1）。相比之下，Tg2576 小鼠在被移动到以前未占用的位置时（实验 2）表现出对熟悉物体的优先探索，无论转换是否改变了物体阵列的度量属性（实验 3）。这些结果表明，Tg2576 小鼠能够形成物体身份的表征以及对竞技场中物体空间组织的记忆。相比之下，老年 Tg2576 小鼠对特定物体位置关联的联合记忆严重受损。
Aged Tg2576 mice show abnormalities in hippocampal morphology and physiology and display behavioral deficits in spatial navigation tasks consonant with a deficit in the functional properties of the hippocampus. However, the nature of the spatial representations disrupted by the "Swedish" mutation of the amyloid precursor protein (APPswe) is unclear. In an effort to characterize the memory deficits in Tg2576 mice, the spontaneous object exploration paradigm was used to interrogate spatial and object memory in mice. With object arrays of comparable size, 16-month-old Tg2576 mice showed a normal object familiarity/novelty effect but impaired memory for the location of objects when 2 objects exchanged locations (topological transformation; Experiment 1). In contrast, Tg2576 mice showed preferential exploration of familiar objects when they were moved to previously unoccupied locations (Experiment 2), irrespective of whether the transformation altered the metric properties of the object array (Experiments 3). These results suggest that Tg2576 mice are able to form representations of the identity of objects and a memory of the spatial organization of objects in an arena. In contrast, conjunctive memory for specific object-location associations is severely impaired in aged Tg2576 mice.