Porous composite prosthetic pylon for integration with skin and bone
Porous composite prosthetic pylon for integration with skin and bone
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DOI：
10.1682/jrrd.2006.12.0160
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发表时间：
2007-01-01
影响因子：
--
通讯作者：
Duz, Volodimir
中科院分区：
文献类型：
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作者：
Pitkin, Mark;Raykhtsaum, Grigory;Duz, Volodimir
本文介绍了“皮骨一体化支架”（SBIP-1）的进一步开发和测试结果，该支架用于经皮（通过皮肤）连接残骨与外部肢体假体。我们研究了一种复合结构（称为SBIP-2）的钛颗粒和细线，使用数学建模和力学测试。结果表明，该支架的强度与解剖骨的强度相当。对30只大鼠进行的体外和体内动物研究表明，复合材料支架的增强并没有损害其先前显示的通过该装置邀请皮肤和骨细胞向内生长的能力。这些发现为重要和治疗物质、信号以及必要的力和力矩从假体器械到身体的安全可靠的长期经皮转移提供了证据。
This article presents results of the further development and testing of the "skin and bone integrated pylon" (SBIP-1) for percutaneous (through skin) connection of the residual bone with an external limb prosthesis. We investigated a composite structure (called the SBIP-2) made of titanium particles and fine wires using mathematical modeling and mechanical testing. Results showed that the strength of the pylon was comparable with that of anatomical bone. In vitro and in vivo animal studies on 30 rats showed that the reinforcement of the composite pylon did not compromise its previously shown capacity for inviting skin and bone cell ingrowth through the device. These findings provide evidence for the safe and reliable long-term percutaneous transfer of vital and therapeutic substances, signals, and necessary forces and moments from a prosthetic device to the body.