ESSENTIAL-HYPERTENSION PREDICTED BY TRACKING OF ELEVATED BLOOD-PRESSURE FROM CHILDHOOD TO ADULTHOOD - THE BOGALUSA HEART-STUDY
ESSENTIAL-HYPERTENSION PREDICTED BY TRACKING OF ELEVATED BLOOD-PRESSURE FROM CHILDHOOD TO ADULTHOOD - THE BOGALUSA HEART-STUDY
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DOI：
10.1016/0895-7061(95)00116-7
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发表时间：
1995-07-01
影响因子：
3.2
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
--
作者：
BAO, WH;THREEFOOT, SA;BERENSON, GS
众所周知，随着时间的流逝，血压（BP）水平持续存在。本研究检查了从童年到成年的BP升高及其发展到必不可少的高血压的跟踪。在社区研究动脉硬化早期自然史和本质高血压的研究中，由两个横断面术> 15年构建了一个纵向群体：1505年：1505年个体（56％的女性受试者，35％黑色），初步研究时5至14岁。BP的持久性通过显着相关性显示在儿童期和成年水平之间（收缩压的r = 0.36至0.50，舒张压bp的r = 0.20至0.42），因种族，性别和年龄而有所不同。控制体重指数（BMI）后，这些相关性保持不变。 15年后，他们的水平处于儿童时期的最高水平，其水平处于最高水平，这是预期的受试者数量的两倍（收缩压的40％，舒张压bp的37％）。此外，在童年特征中，基线BP水平最可预测随访水平，随后是BMI的变化。随后，即使在20至31岁时，临床诊断的高血压的患病率在儿童BP的受试者中也要高得多。在最高五分位数中：收缩BP高3.6倍（18％V 5％），舒张压bp高2.6倍（15％V 5.8％），与其他五分之一的主题相比。在出现高血压的116名受试者中，有48％和41％的儿童收缩期和舒张压升高。在黑人，童年时BP或BMI较高或从童年到成年的受试者中，成年后发生的高血压更为普遍。多次检查增强了先前BP水平的高血压预测。估计从419名参加其他四项调查的受试者中，多次表现出BP水平升高的个体更有可能发展未来的高血压。高级BP水平随着时间的流逝而持续存在，并发展为成人高血压。重复测量BP生命早期可以改善成人高血压的预测。
It is well known that blood pressure (BP) levels persist over time. The present investigation examines tracking of elevated BP from childhood to adulthood and its progression to essential hypertension.In a community study of early natural history of arteriosclerosis and essential hypertension, a longitudinal cohort was constructed from two cross-sectional surveys >15 years apart: 1505 individuals (56% female subjects, 35% black), aged 5 to 14 years at initial study.Persistence of BP was shown by significant correlations between childhood and adulthood levels (r = 0.36 to 0.50 for systolic BP and r = 0.20 to 0.42 for diastolic BP), varying by race, sex, and age. These correlations remained the same after controlling for body mass index (BMI). Twice the expected number of subjects (40% for systolic BP and 37% for diastolic BP), whose levels were in the highest quintile at childhood, remained there 15 years later. Furthermore, of the childhood characteristics, baseline BP level was most predictive of the follow-up level, followed by change in BMI.Subsequently, even at ages 20 to 31 years, prevalence of clinically diagnosed hypertension was much higher in subjects whose childhood BP was in the top quintile: 3.6 times (18% v 5%) as high in systolic BP and 2.6 times (15% v 5.8%) as high in diastolic BP, compared to subjects in every other quintile. Of the 116 subjects who developed hypertension, 48% and 41% had elevated childhood systolic and diastolic BP, respectively. Hypertension that developed in early adulthood was more prevalent in blacks, in subjects who had higher BP or BMI in childhood, or had gained more BMI from childhood to adulthood. The prediction of hypertension by earlier BP level was enhanced by multiple examinations. Estimated from 419 subjects who participated in four other surveys, individuals showing elevated BP levels at multiple times were more likely to develop future hypertension.Elevated BP levels persist over time and progress to adult hypertension. Repeated measurements of BP early in life improve the prediction of adult hypertension.