Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19
Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19
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DOI：
10.1016/j.xcrm.2020.100078
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发表时间：
2020-08-25
影响因子：
14.3
通讯作者：
Brodin, Petter
中科院分区：
文献类型：
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作者：
Rodriguez, Lucie;Pekkarinen, Pirkka T.;Brodin, Petter
SARS-CoV-2 严重疾病的特点是肺部剧烈炎症反应，通常在疾病稳定 5-7 天后突然发病。调节这种过度炎症和相关的急性呼吸窘迫综合征的努力依赖于解开驱动这种反应的免疫细胞相互作用和细胞因子。鉴于每个患者都处于感染的不同阶段，因此对免疫反应的纵向监测至关重要，并且需要进行系统级分析来捕获细胞相互作用。在此，我们报告了一项系统级血液免疫监测研究，该研究对 37 名被诊断患有 COVID-19 的成年患者进行了系统级血液免疫监测研究，并跟踪了从疾病急性期到恢复期的多达 14 份血液样本。我们描述了肺部过度炎症之前激活的 IFNg-嗜酸性粒细胞轴以及疾病不同阶段细胞间共同调节的变化。我们还绘制了重症 COVID-19 患者康复期间的免疫轨迹。
Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts tomodulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNg-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.